24721-26-4

Basic information

• Product Name: 2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (Z)-
• CAS NO: 24721-26-4
• Molecular Formula: C15H11ClO
• Molecular Weight: 242.705
• Mol File: 24721-26-4.mol
• Article Data: 163

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (Z)-(24721-26-4)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-chlorophenyl)-1-phenyl-, (Z)-(24721-26-4)

Safety Data

• Hazardous Substances Data: 24721-26-4(Hazardous Substances Data)

Upstream product

• 24721-26-4 4-chlorochalcone 
• 104-88-1 4-chlorobenzaldehyde 
• 70-11-1 α-bromoacetophenone 
• 905811-24-7 [[3-(4-chlorophenyl)-1-phenyl-2-propynyl]oxy]-trimethylsilane 
• 873-73-4 4-n-chlorophenylacetylene 
• 944551-28-4 3-(4-chlorophenyl)-1-phenylprop-2-yn-1-ol 
• 100-52-7 benzaldehyde 
• 133961-78-1 [1-(4-Chloro-phenyl)-3-oxo-3-phenyl-propylsulfanyl]-acetic acid 
• 111873-49-5 Te-phenacyldi(n-butyl)telluronium bromide 
• 536-74-3 phenylacetylene 
• 99-91-2 para-chloroacetophenone 
• 583-06-2 3-benzoylacrylic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1678-18-8 (2-oxo-2-phenylethyl)-triphenylphosphonium chloride 

Downstream Products

• 89451-24-1 4-(4-Chloro-phenyl)-6-hydroxy-6-phenyl-2-thioxo-piperidine-3-carbonitrile; compound with piperidine 
• 74007-56-0 2-(4-Chloro-phenyl)-3,3-dimethoxy-1-phenyl-propan-1-one 
• 101855-02-1 3-(4-chloro-phenyl)-3-methoxyamino-1-phenyl-propan-1-one 
• 144765-45-7 (1R*,2R*,3S*,4S*,6S*)-(+/-)-2,6-Bis-(4-chlorophenyl)-3-benzoyl-1-(4-bromophenyl)-4-hydroxy-4-phenylcyclohexanecarbonitrile 
• 24721-26-4 4-chlorochalcone 
• 138982-96-4 3-(4-chlorophenyl)-1-phenyl-1-pentanone 
• 143968-99-4 4-(4-Chloro-phenyl)-6-phenyl-pyridin-2-ol 
• 95855-32-6 2-(4-chlorophenyl)-4-oxo-4-phenylbutanenitrile 
• 137594-15-1 4-(4-Chloro-phenyl)-6-phenyl-3-aza-tricyclo[8.4.1.0^2,7]pentadeca-1⁽¹⁴⁾,2⁽⁷⁾,3,8,10,12-hexaene 
• 107710-40-7 Dithiocarbamic acid 1-(4-chloro-phenyl)-3-oxo-3-phenyl-propyl ester 
• 72028-26-3 3-(4-Chlorphenyl)-5-oxo-5-phenylpentansaeure 
• 80674-55-1 5-(4-Chlorphenyl)-3-hydroxy-3-phenyl-(E)-4-pentensaeure 
• 6969-01-3 ((2S,3R)-3-(4-chlorophenyl)oxiran-2-yl)(phenyl)methanone 
• 6969-01-3 ((2R,3S)-3-(4-chlorophenyl)oxiran-2-yl) (phenyl)methanone 

Relevant articles and documents

Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes

We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.

A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Chemoselective reduction of ?,￠-unsaturated carbonyl and carboxylic compounds by hydrogen iodide

The selective reduction of ?,￠-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an ? or ￠ position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce ￠-iodo compounds followed by the reduction of C-I bond via anionic and radical paths.