Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes
N-methylamino derivatives of biologically active substances which have enhanced delivery across topical membranes and pharmaceutical compositions adapted for topical administration containing same.
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(2008/06/13)
ANALOGS OF PYRIMIDINE NUCLEOSIDES. 20. AMINOMETHYLATION OF 5-FLUOROURACIL AND THYMINE
Reactions were studied of 5-fluorouracil and thymine with formaldehyde and secondary amines (piperidine, morpholine) and also of their 2,4-bis(trimethylsilyl) derivatives with N-methoxymethylmorpholine and bis(amino)methanes.The N-aminomethylation products are slightly stable and in aqueous solutions decompose readily to the starting components; their structure was confirmed by PMR spectra.
Zhuk, R. A.,Ludzisha, A. S.,Kostyanovskii, R. G.
p. 74 - 77
(2007/10/02)
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