111982-48-0

Basic information

• Product Name: Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]-
• CAS NO: 111982-48-0
• Molecular Formula: C13H16FNO
• Molecular Weight: 221.27100
• Mol File: 111982-48-0.mol

Chemical Properties

• CAS DataBase Reference: Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]-(111982-48-0)
• EPA Substance Registry System: Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]-(111982-48-0)

Safety Data

• Hazardous Substances Data: 111982-48-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]is used as a pharmaceutical intermediate for the synthesis of various medicinal compounds. Its unique structure, including the fluorophenyl and methylimino groups, may contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]may be utilized as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides. Its structural features could potentially enhance the effectiveness of these products and contribute to more sustainable agricultural practices.
Used in Materials Science:
Cyclopentanol, 1-[(2-fluorophenyl)(methylimino)methyl]may also find applications in materials science, where its unique structure could be employed to develop new materials with specific properties. These materials could have potential uses in various industries, such as electronics, coatings, or adhesives, depending on the desired characteristics.

Upstream product

• 1616657-67-0 α-bromocyclopentyl-(2-fluorophenyl)ketone 
• 74-89-5 methylamine 
• 111982-45-7 cyclopentyl(2-fluorophenyl)methanone 
• 394-47-8 2-fluorobenzonitrile 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 111982-50-4 (±)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone 

Relevant articles and documents

ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS

Provided herein are arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders.

Synthesis of 2-(2-fluorophenyl)-2-methylamino-cyclohexanone as a new ketamine derivative

The main goal of this article is to the present research on the development of ketamine derivatives. The target molecule was a fluoroderivative of ketamine, for which a multistep synthesis has been reported. This novel ketamine derivative, 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, has been called fluoroketamine by our research group. The starting fluorobenzonitrile was reacted with the appropriate Grignard reagent followed by the bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at -40 °C then resulted in the formation of α-hydroxycyclopentyl-(2-flourophenyl)-N-methylamine. Finally, the five-memberd ring cyclopentanol was expanded to the cyclohexylketone by a thermal rearrangement reaction. The HCl salt of the target molecule, which is soluble in water, was obtained by the acidification of the free fluoroketamine with HCl. Preliminary animal tests on mice have shown that the resulting fluoroketamine has some advantages over ketamine in terms of the effective dose and the recovery time. Copyright