This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
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Page/Page column 93; 94
(2021/03/05)
Modular Access to Azepines by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes
A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C-C bond activation of aminocyclopropanes provides rhodacyclopentanones. These intermediates are effective for intramolecular C-H metalation of either an N-aryl or N-vinyl unit en route to azepine ring systems. Thus, byproduct-free heterocyclizations are enabled by sequential C-C activation and C-H functionalization steps.
Wang, Gang-Wei,Bower, John F.
supporting information
p. 2743 - 2747
(2018/03/06)
A general animation method based on the addition of polyfunctional arylmagnesium reagents to functionalized arylazo tosylates
A one-pot reaction sequence consisting of a Grignard reaction, allylation, and reduction provides new functionalized diarylamines in good yields (see scheme, Ts = toluene-4-sulfonyl, NMP = N-methylpyrrolidine, TFA = trifluoroacetic acid). In the first ste
Sapountzis, Ioannis,Knochel, Paul
p. 897 - 900
(2007/10/03)
N-Cyclopropylation of Aromatic Amines
Various aromatic amines have been N-cyclopropylated in excellent overall yields in a two-step sequence of 1-ethoxycyclopropylation followed by reduction.
Kang, Jahyo,Kim, Koan Sung
p. 897 - 898
(2007/10/02)
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