- An efficient protocol for the synthesis, biological screening and molecular docking studies of 3,4-dihydropyrimidine-2-one/thione derivatives
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Introduction: Heterocyclic compounds are vital to life, since they constitute the most interesting part of the pharmacologically active drugs. Dihydropyrimidine-2-one/thione (DHPM) as the heterocyclic nucleus is the basic part of the most natural as well
- Farooq, Hafiz Umar,Fatima, Nighat,Javed, Chaudhary Omer,Manan, Abdul,Mughal, Ehsan Ullah,Muhammad, Syed Aun,Rafique, Hummera,Sadiq, Amina,Sumrra, Sajjad Hussain,Tayyab, Muhammad,Zafar, Muhammad Naveed
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p. 330 - 340
(2020/04/17)
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- Sulfonic acid-functionalized polypropylene fiber: Highly efficient and recyclable heterogeneous Bronsted acid catalyst
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A sulfonic acid-functionalized polypropylene fiber, capable of acting as a supported catalyst in the accomplishment of the Biginelli reaction, is presented. Excellent results, in terms of chemical yields, catalyst dosage, work-up procedure and catalytic r
- Shi, Xian-Lei,Yang, Huixiao,Tao, Minli,Zhang, Wenqin
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p. 3939 - 3945
(2013/04/24)
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- A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions
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The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.
- Pasunooti, Kalyan Kumar,Chai, Hua,Jensen, Chantel Nixon,Gorityala, Bala Kishan,Wang, Siming,Liu, Xue-Wei
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supporting information; experimental part
p. 80 - 84
(2011/02/25)
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- Synthesis of alkyl 6-methyl-4-(2-trifluoromethylphenyl)-1,2,3,4-tetrahydro- 2H-pyrimidine-2-one-5-carboxylates possessing a N-3 nitro substituent to determine calcium channel modulation structure-activity relationships
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(Chemical Equation Presented) The Bigenelli acid catalyzed condensation of 2-trifluoromethylbenzaldehyde (1), urea (2) and an alkyl acetoacetate (3) afforded the respective alkyl (Me, Et, i-Pr, i-Bu) 6-methyl-4-(2- trifluoromethylphenyl)-1,2,3,4-tetrahydr
- Kaur, Kuljeet,Knaus, Edward E.
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p. 669 - 672
(2008/09/17)
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- Microwave induced eco-friendly solvent-free Biginelli reaction catalyzed by calcium chloride
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An efficient one-pot rapid synthesis of 4-aryl-3, 4-dihydropyrimidine-2- (1H)-ones/thiones (DHPMs) involving CaCl2 catalyzed Biginelli three-component condensation under microwave irradiation in a solvent-free condition is reported.
- Misra, Anup Kumar,Agnihotri, Geetanjali,Madhusudan, Soni Kamlesh
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p. 2018 - 2020
(2007/10/03)
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- Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4- dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
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A series of pharmacologically active, functionalized 4-aryl-3,4- dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4- dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.
- Kappe, C. Oliver
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- Microwave-assisted high-speed parallel synthesis of 4-aryl-3,4- dihydropyrimidin-2(1H)-ones using a solventless biginelli condensation protocol
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4-Aryl-3,4-dihydropyrimidin-2-(1H)-ones 4a-o are synthesized by a microwave-promoted, solvent-free modification of the Biginelli three- component cyclocondensation reaction. The novel method employs neat mixtures of β-ketoesters, aryl aldehydes, and urea
- Kappe, C. Oliver,Kumar, Dalip,Varma, Rajender S.
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p. 1799 - 1803
(2007/10/03)
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- Polyphosphate ester-mediated synthesis of dihydropyrimidines. Improved conditions for the Biginelli reaction
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Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction c
- Kappe, C. Oliver,Falsone, S. Fabio
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p. 718 - 720
(2007/10/03)
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- SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-5-PYRIMIDINECARBOXYLIC ACID ESTERS: THE BIGINELLI CONDENSATION REVISITED
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A general synthesis of substituted 1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid esters from 2-methylene-3-oxobutanoic acid esters and O-methylisourea hydrogen sulfate is reported.
- O'Reilly, Brian C.,Atwal, Karnail S.
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p. 1185 - 1188
(2007/10/02)
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