- Oxyhalogen-sulfur chemistry: Oxidation of a thiourea dimer, formamidine disulfide, by chlorine dioxide
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The oxidation of formamidine disulfide, FDS, the dimer of thiourea, by aqueous chlorine dioxide has been studied in highly acidic and mildly acidic media. FDS is one of the possible oxidation intermediates formed in the oxidation of thiourea by oxyhalogens to urea and sulfate. The reaction is exceedingly slow, giving urea and sulfate with a stoichiometric ratio of 5:14 FDS to chlorine dioxide after an incubation period of up to 72h and only in highly acidic media which discourages the disproportionation of chlorine dioxide to the oxidatively inert chlorate. Mass spectrometric data suggest that the oxidative pathway proceeds predominantly through the sulfinic acid, proceeding next to the products sulfate and urea, while by-passing the sulfonic acid. Transient formation of the unstable sulfenic acid was also not observed.
- Martincigh, Bice S.,Mhike, Morgen,Morakinyo, Kayode,Adigun, Risikat Ajibola,Simoyi, Reuben H.
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Read Online
- Solvent-free ring cleavage hydrazinolysis of certain biginelli pyrimidines
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Certain Biginelli pyrimidines with ester substitution in C5 were subjected to unexpected ring opening upon solvent-free reaction with hydrazine hydrate to give three products: pyrazole, arylidenehydrazines, and urea/thiourea, respectively. The nonisolable carbohydrazide intermediates are formed firstly followed by the intermolecular nucleophilic attack of terminal amino group of hydrazide function on sp2 C6 rather than the sp3 C4 to give the ring adduct which was produced as a final product.
- Said, Mohamed A.,Eldehna, Wagdy M.,Ghabbour, Hazem A.,Kabil, Maha M.,Al-shakliah, Nasser S,Abdel-Aziz, Hatem A
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Read Online
- Electrooxidation of Formamidine Disulfide Simultaneously Investigated by On-Line High Performance Liquid Chromatography and Cyclic Voltammetry
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The electro-oxidation of formamidine disulfide, an important sulfur-containing compound, was simultaneously investigated with on-line high-performance liquid chromatography and cyclic voltammetry. Using a home-made microporous sampler located at the electrode interface, the solution on the electrode surface was in situ sampled and analyzed. The electrochemical scanning was synchronously performed, which allowed the electro-oxidation products to be detected at a given potential. The main products on the surface of platinum electrode were found to be thiourea, formamidine sulfinic acid, cyanamide, and elemental sulfur. Forced convection arising from the sampling played an important role in the electrochemical oxidation. The extraction of electrode surface solution promoted the renewal of reactant and its intermediates, which induced the change of cyclic voltammetry curve. The forced convection also contributed to the redox peak current of the species on the cyclic voltammetry curves through the change of concentration of reactant and its intermediates. This technique can help to explore the reaction mechanism of complex electrochemical reactions.
- Feng, Na,Li, Fengli,Liu, Yang,Luo, Hainan,Zhang, Baoying,Zhang, Wei,Zhao, Yuyan
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p. 1074 - 1080
(2021/11/03)
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- Photooxygenation of N-(2-thiazolyl)sulfanilamide, 2-(4-thiazolyl) benzimidazole, and thiacetazone
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In the present work, photolysis of N-(2-thiozolyl)sulfanilamide, 2-(4-thiazolyl)benzimidazole and thiacetazone in presence of benzophenone as a sensitizer under 125 W UV Lamp has been reported. Structures of the products have been established by spectral and elemental analysis.
- Jain, Shubha,Chourey, Meena,Jetti, Srinivasa Rao
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p. 155 - 157,3
(2020/09/09)
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- Kinetic study on hydrolysis and oxidation of formamidine disulfide in acidic solutions
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Hydrolysis and oxidation of formamidine disulfide in acidic medium were investigated using high-performance liquid chromatography (HPLC) and mass spectrometry (MS) at 25 °C. By controlling the slow reaction rate and choosing appropriate mobile phase, HPLC provides the unique advantages over other methods (UV-Vis, chemical separation) in species tracking and kinetic study. In addition to thiourea and formamidine sulfinic acid, two unreported products were also detected in the hydrolysis reaction. Mass spectrometry measurement indicates these two products to be formamidine sulfenic acid and thiocyanogen with mass weights of 92.28 and 116.36, respectively. In the oxidation of formamidine disulfide by hydrogen peroxide, besides thiourea, formamidine sulfenic acid, formamidine sulfinic acid, thiocyanogen and urea, formamidine sulfonic acid and sulfate could be detected. The oxidation reaction was found to be first order in both formamidine disulfide and hydrogen peroxide. The rate constants of hydrolysis and oxidation reactions were determined in the pH range of 1.5-3.0. It was found both rate constants are increased with the increasing of pH. Experimental curves of different species can be effectively simulated via a mechanism scheme for formamidine disulfide oxidation, including hydrolysis equilibrium of formamidine disulfide and irreversible hydrolysis of formamidine sulfenic acid.
- Hu, Ying,Feng, Jiamin,Li, Yanwei,Sun, Yanyan,Xu, Li,Zhao, Yuemin,Gao, Qingyu
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experimental part
p. 235 - 241
(2012/03/22)
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- Hydrolysis of 2,4-dithiophenobarbital
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Hydrolysis of 2,4-dithiophenobarbital in aqueous solutions of pH 2 - 12 was investigated at 40 and 60°C using UV spectrophotometry. The values of reaction order, rate constants, pKal and pKa2 and activation energy were determined. The preliminary estimation of degradation products was accomplished using thin layer chromatography. The major products were isolated by circular chromatography and identified by spectroscopic and classical methods.
- Tarsa, Monika,Zuchowski, Grzegorz,Stasiewicz-Urban, Anna,Bojarski, Jacek
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experimental part
p. 123 - 128
(2009/06/20)
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- Desulfurization and transformation of isothiocyanates to cyanamides by using sodium bis(trimethylsilyl)amide
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Sodium bis(trimethylsilyl)amide was first used as the desulfurizing agent for the conversion of isothiocyanates to cyanamides in a 'one-flask' reaction. Crown Copyright
- Chen, Chun-Yen,Wong, Fung Fuh,Huang, Jiann-Jyh,Lin, Shao-Kai,Yeh, Mou-Yung
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supporting information; scheme or table
p. 6505 - 6507
(2009/04/06)
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- Stereocontrolled synthesis of functionalized cis-cyclopentapyrazolidines by 1,3-dipolar cycloaddition reactions of azomethine imines
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(Chemical Equation Presented) The reaction of alkene-tethered α-ketocarboxylic acid derivatives with monosubstituted hydrazines allows highly substituted cis-cyclopentapyrazolidine ring systems 4 to be constructed rapidly. Successful cyclocondensations are realized under thermal reaction conditions; in some cases, protic or Lewis acids accelerate these reactions. α-Methoxy-α,β-unsaturated esters are suitable alkene components, as are alkenes having either electron-withdrawing or electron-donating substituents at the terminal alkene carbon. α-Ketoesters, α-ketoamides, and α-ketothioesters can be employed. Various hydrazines substituted with N-acyl, N-carboalkoxy, or N-carbamothioyl protecting groups are tolerated in these transformations. The rate of intramolecular cycloaddition is found to reflect not only the reactivity and equilibrium concentration of the azomethine imine intermediate, but, also in some cases, the rate at which hydrazone stereoisomers interconvert under the reaction conditions.
- Gergely, Joshua,Morgan, Jeremy B.,Overman, Larry E.
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p. 9144 - 9152
(2007/10/03)
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- Substitute 1-(piperidin-4-yl)-3-(aryl)-isothioureas, their preparation and therapeutic use
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The invention concerns compounds of formula (I) wherein: R1 and R2, identical or different, represent a saturated or unsaturated alkyl radical, branched or not and containing 1 to 7 carbon atoms; R3 to R8, identical or different, represent a hydrogen, an alkyl branched or not and containing 1 to 5 carbon atoms, an acyloxy, branched or not and containing 1 to 5 carbon atoms, a halogeno, nitro, hydroxy, acyl or alkoxy group containing 1 to 5 carbon atoms, a dialkylamino group containing 1 to 5 carbon atoms, a trifluoromethyl or trifluoro methoxyl group; Z represents an oxygen or sulphur atom or methylene; m represents an integer between 0 and 4 inclusively; n represents an integer between 2 and 7 inclusively; and their pure enantiomers and mixtures, the therapeutically acceptable mineral or organic salts of the compounds of formula (I) and their possible hydrates.
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- Compounds for the modulation of PPARgamma activity
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Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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- Il-8 receptor anatagonists
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This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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- Compounds useful as reversible inhibitors of cysteine proteases
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Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.
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- Transition metal mediated process
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This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.
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- Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
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The invention relates to novel compounds of the type of the imidazolidines of the formula I in which R1 to R7 are as defined herein. In one embodiment, these compounds are used for the treatment of the central nervous system, of lipid metabolism, of infec
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- Hepatitis C inhibitor tri-peptides
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Disclosed herein are compounds of formula (1): wherein R1is hydroxy or NHSO2R1Awherein R1Ais (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or R1Ais C6or C10aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6) alkyl, amido, amino or phenyl; R2is (C4-6)cycloalkyl; R3is t-butyl or (C5-6) cycloalkyl and R4is (C4-6)cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of HCV NS3 protease.
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- Hepatitis C inhibitor tri-peptides
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Disclosed herein are compounds of formula (1): wherein Ris hydroxy or NHSO2Rwherein Ris (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O-(C1-6)alkyl, amido, amino or phenyl, or Ris C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O-(C1-6) alkyl, amido, amino or phenyl; Ris (C4-6)cycloalkyl; Ris t-btuyl or (C5-6) cycloalkyl and Ris (C4-6)cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of HCV NS3 protease.
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- Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them
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The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a medicament comprising them. in which R1 to R9 have the meanings shown in the claims.
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- Novel compounds useful as reversible inhibitors of cysteine proteases
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Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The co
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- Thiazole derivatives
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Compounds of the formula: as well as pharmaceutically usable salts and esters thereof, wherein R1, R2 and R3 have the significance ascribed herein, inhibit binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. These compounds can be used in the form of pharmaceutical preparations for the control or prevention of neoplasms, tumor metastasing, tumor growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure, as well as infection caused by viruses, bacteria or fungi.
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- The development of a manufacturable synthesis of LY213829
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The development of a manufacturable synthesis of LY213829 (4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl] methyl) is described. Rather than reduction to eliminate the thiocarbonyl from the rhodanine moiety, the new route utilizes a novel
- Slattery, Brian J.,Kjell, Douglas P.,Copp, James D.,Ginah, Francis O.,Hansen, Marvin M.,Stirm, Stephen C.
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p. 295 - 297
(2013/09/07)
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- Benzodiazepine derivatives
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Compounds of Formula (I), and salts and prodrugs thereof, wherein said formula, R 1 represents certain optionally substituted alkyl or C 3-7 cycloalkyl; R 2 represents (II) or (III), where m is 0, 1, 2 or 3; R 9 is H or C 1-6 alkyl; R 10 is imidazolyl, triazolyl or tetrazolyl, and R 11 is H, C 1-6 alkyl or halo; R 3 is C 1-6 alkyl, halo or NR 6 R 7 ; R 4 is C 1-7 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-4 alkyl, C 6-10 bicycloalkyl, optionally substituted aryl, or NR 12 R 13 ; R 5 is H or C 1-4 alkyl; n is 0, 1, 2 or 3; which are CCK and/or gastrin antagonists useful in therapy.
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- Kinetic study of the stability of (NH2)2CSSC(NH2)22+
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The kinetics of the decomposition of formamidine disulfide dihydrochloride, (NH2)2CSSC(NH2)22+ 2Cl-, in aqueous solution at 25 degC are general base catalysed, and rate constants have been measured over the pH range 1.91-9.03.Analysis of the data yields ionisation constants pK1 = 5.49, pK2 = 7.66 and rate constants for deprotonation of the substrate by OH- and H2O.For the doubly charged cation, reaction occurs through a small concentration of a reactive tautomer, (HN=)(NH3+)CSSC+(NH2)2, which is attacked by H2O.The singly charged cation reacts by parallel pathways involving OH- and H2O as attacking bases.
- Rio, L. Garcia,Munkley, Carl G.,Stedman, Geoffrey
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p. 159 - 162
(2007/10/03)
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- Pharmaceutical composition for inhibiting HIV protease
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A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a mixture of (1) (a) a solvent selected from propylene glycol and polyethylene glycol or (b) a solvent selected from polyoxyethyleneglycerol triricinoleate, polyethylene glycol 40 hydrogenated castor oil, fractionated coconut oil, polyoxyethylene (20) sorbitan monooleate and 2-(2-ethoxyethoxy)ethanol or (c) a mixture thereof and (2) ethanol or propylene glycol.
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- Pharmaceutical composition
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A solid pharmaceutical composition is disclosed which comprises a pharmaceutically acceptable adsorbent or a mixture of pharmaceutically acceptable adsorbents to which is adsorbed a mixture of (1) a pharmaceutically acceptable organic solvent or a mixture of pharmaceutically acceptable organic solvents, (2) an HIV protease inhibiting compound and (3) one or more pharmaceutically acceptable acids. The solid composition can optionally be encapsulated in a hard gelatin capsule.
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- Therapeutic heterocycles which antagonize neurokinin receptors
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Compounds of formula I STR1 wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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- Electroreduction of Some Potential Antimicrobial Thiosemicarbazide Derivatives of Quinazolin-4(3H)-one
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Polarographic data for a series of 3-phenyl-2-substituted thiocarbamoylhydrazonomethylquinazolin-4(3H)-ones (with antimicrobial activity), in 50percent ethanolic aqueous buffers covering a wide range of pH are reported and discussed.A mechanism interpreting the electrode process, in both acidic and alkaline media, is proposed and confirmed via the identification of CPE products, Hammett's ?-E1/2 relation and pKa determination.
- Ismail, Mohamed I.
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p. 585 - 590
(2007/10/02)
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- Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
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A series of ethers and thioethers of 5-methanol thiohydantoins, unsubstituted at the number one position heterocyclic nitrogen atom of the thiohydantoin ring, useful in reversing the effects of collagen and ADP-induced platelet aggregation.
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- Sweetening agents
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Substituted guanidines and ethanamidines are provided as high potency sweetening agents.
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- Iminophenylthiazolidines, process of preparation and method of use
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A 2-iminophenyl thiazolidine having the formula STR1 wherein R is hydrogen or methyl; R1 is halo, nitro, cyano, C1 -C4 alkyl, C1 -C4 alkoxy, perhalomethyl, difluoromethyl, pentafluoroethyl, trifluoromethylthhio, difluoromethoxy, trifluoromethoxy, tetrafluoroethoxy, methylsulfonyl, C1 -C4 alkyloxyiminomethyl, benzyloxyiminomethyl, 1-(C1 -C4 alkyl)-oxyiminoethyl or 1-benzyloxyiminoethyl; R2 is hydrogen or halo; R3 and R4 are independently hydrogen, halo, nitro, cyano, C1 -C4 haloalkyl, C1 -C4 alkyl, C1 -C4 fluoroalkoxy, C1 -C4 alkoxy or C1 -C4 alkylthio; and X is hydrogen or halogen. Also disclosed is a process for making the compounds and a method of use which comprises applying the compound or composition to the locus where control is desired.
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- High potency sweetening agents
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Substituted guanidines containing a tetrazole moiety are provided as high potency sweetening agents.
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- REACTIONS OF 1,3-DIACYLTHIOUREAS WITH METHOXIDE ION AND WITH AMINES
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Rate constants of base-catalyzed methanolysis and dissociation constants in methanol have been determined for benzylthiourea (II), 1,3-diacetylthiourea (III), 1,3-dibenzoylthiourea (IV), and 1-acetyl-3-benzoylthiourea (V).With the diacyl derivatives III and IV, the reaction of methoxide ion with the neutral substrate is accompanied by that of methoxide with the substrate anion (at higher alkoxide concentrations).Above 0.1 mol l-1 CH3O(-), the rate constants are also affected by medium.The rate of the reaction of neutral diacyl derivative is decreased, and that of the reacti on of methoxide with the substrate anion is rapidly increased.The dissociation constant of II is higher than that of acetylthiourea (I) by about one order of magnitude, but the attack of methoxide on the carbonyl group of II is about three times slower than that in I.The benzoyl group at the N1 nitrogen exhibits a greater activating influence (in both the rate and the equilibrium constants) on the other NHCOR group than the acetyl group does.With V the ratio of methanolysis rate constants is 9:1 in favour of the acetyl group.The reaction of diacetyl derivative III with 1-butanamine has been followed in butanamine buffers.At the lowest butanamine concentrations, the reaction is second order in the amine, and the rate-limiting step is the proton transfer from the intermediate to the second amine molecule.At the highest butanamine concentrations the reaction becomes first order in the amine, and the rate limiting step changes to the attack of butanamine on the carbonyl group of diacetyl derivative III.
- Kavalek, Jaromir,Jirman, Josef,Sterba, Vojeslav
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p. 120 - 131
(2007/10/02)
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- Novel bicyclooxyaryl thioureas and process for preparation
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Novel bicyclooxyaryl thioureas are provided together with methods for their preparation and use as the active toxicant in pesticidal compositions.
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- PHOTOCHEMICAL DEGRADATION OF BARBITURIC ACID DERIVATIVES. PART VII. PHOTOLYSIS OF 5,5-DIETHYL-2-THIOBARBITURIC ACID
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The photodegradation of 5,5-diethyl-2-thiobarbituric acid in buffered aqueous and non-aqueous media was investigated.The main products of photolyses in anhydrous ethanol and n-propanol were identified as 2-alkoxy-5,5-diethyldihydro-4,6(1H,5H)-pyrimidinediones.The pathway of their formation has been suggested.
- Paluchowska, Maria,Bojarski, Jacek
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p. 825 - 830
(2007/10/02)
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- KINETICS AND MECHANISM OF REARRANGEMENT AND METHANOLYSIS OF ACYLPHENYLTHIOUREAS
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S-Acyl-1-phenylthioureas and their 3-methyl derivatives are rearranged to 1-acyl derivatives of thiourea in methanolic solution.The rearrangement of the 1-acyl-1-phenyl derivative to the thermodynamically more stable 3-acyl derivative is subject to specific base catalysis.The rearrangement of acetyl group is about 2 orders of magnitude slower than that of benzoyl group. 1-Acetyl-1-phenylthiourea undergoes base-catalyzed methanolysis (giving phenylthiourea and methyl acetate) instead of the rearrangement.The methanolysis rates of 1-acyl-3-phenylthioureas and their N-methyl derivatives have been measured.The acetylthioureas react at most 3 x faster than the benzoyl derivatives.The methyl group at the nitrogen adjacent to acyl group accelerates the solvolysis by almost 2 orders of magnitude; the methyl group at the other nitrogen atom retards the solvolysis by almost 1 order of magnitude.Replacement of hydrogen atom by methyl group at the phenyl-substituted nitrogen increases acidity of the phenylacetylthiourea by 2 orders of magnitude.The same replacement at the benzoyl-substituted nitrogen increases the acidity by 3 orders of magnitude, the increase in the case of the acetyl derivative being as large as 4 orders of magnitude.
- Kavalek, Jaromir,Jirman, Josef,Sterba, Vojeslav
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p. 766 - 778
(2007/10/02)
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- AN INVESTIGATION OF THE TRANSFORMATIONS OF 2-AMINO-2-THIAZOLIN-4-ONE AND ITS DERIVATIVES IN AQUEOUS SOLUTIONS
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It has been shown by thin-layer radiochromatography that the action of an aqueous solution of alkali on 2-amino-2-thiazolin-4-one and its 5-alkyl derivatives leads predominantly to the opening of the ring by a mechanism similar to the opening of lactams in an alkaline medium.
- Fedoseev, V. M.,Mandrugin, A. A.,Semenenko, M. N.
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- Imidazolylphenyl amidines, pharmaceutical compositions containing same and use thereof
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This invention relates to imidazolylphenyl amidines, the preparation thereof, and pharmaceutical compositions containing them. More particularly, this invention relates to compounds of the general formula STR1 in which R, R1, R3, whi
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- KINETICS OF HYDROLYSIS AND REARRANGEMENTS OF S-ACYLTHIOURONIUM SALTS
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Kinetics of transformation of S-acetyl- and S-benzoylisothiouronium chlorides have been followed, and its reaction products in dilute hydrochloric acid media and aqueous buffers have been identified.In dilute hydrochloric acid the reaction rate is pH-independent, and the acetyl derivative reacts 8 times as rapidly as the benzoyl derivative.In acetate and phosphate buffers the decomposition rate of the both derivatives increases linearly with the buffer concentration.In acetate buffers the reaction rate is pH-independent, and acetate ion reacts as a nucleophile, In phosphate buffers the rate increases with increasing pH.The reaction catalyzed by the basic buffer component produces thiourea and carboxylic acid, that catalyzed by hydroxyl ion produces N-acetyl- or N-benzoylthiourea.The solvolysis rates of the both S-acyl derivatives depend on percent composition of water-methanol solvent.The maximum solvolysis rate is reached in methanol with 25percent (v/v) water.
- Kavalek, Jaromir,Novak, Jaroslav,Sterba, Vojeslav
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p. 2702 - 2710
(2007/10/02)
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- Compounds, compositions and methods for controlling pests
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A new method of controlling pests harmful to domestic animals and certain novel pesticidal compositions are described. Compounds for use in the method have the formula STR1 in which n is 0 to 5, R is halo, alkyl, trihaloalkyl, cyano alkoxy or alkoxycarbon
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- Oxidation of Mixtures of Thioureas: Part VIII - Formation of 3-Amino-4-aryl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazoles
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Oxidation of binary mixtures of 1-aryl-3-benzylthioureas and thiourea in acidic ethanol affords 3-amino-4-aryl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazoles (3). 1-Aryl-3-benzylthioureas used are: 1-phenyl-3-benzyl-, 1-p-tolyl-3-benzyl-, 1-benzyl-3-p-chlorophenyl-, 1-p-anisyl-3-benzyl- and 1-benzyl-3-p-nitrophenyl-thioureas.
- Indukumari, P. V.,Joshua, C. P.
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p. 672 - 675
(2007/10/02)
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- Benzhydryl guanidines
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Benzhydryl derivatives of guanidine (Formula I) having blood sugar lowering activity; pharmaceutical hypoglycemic compositions thereof and methods of administering same to hyperglycemic individuals.
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- Adamantyl containing guanidines
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Novel compounds of FIG. 1, pharmaceutical compositions thereof, and systemic means of administration for anti-arrhythmic and diuretic uses are disclosed: STR1
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- Substituted morpholine guanidines for the treatment of arrhythmic conditions
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The pharmaceutical compositions and methods of using these compositions for anti-arrhythmic and diuretic uses are disclosed for the compounds below: EQU1
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