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112193-35-8

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A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
Kiselev,Machula,Efimov,Pashkova,Stovbun
p. 615 - 619
(2019/07/17)

Synthesis and pharmacological activity of amino acid derivatives of nicotinic acid
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Kuznetsova,Voronina,Khromova,Garibova,Tosina,Stolyarova,Troitskaya,Smirnov
p. 943 - 949
(2007/10/02)

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Chemical Properties

Boiling Point: 704.7°Cat760mmHg
Flash Point:380°C
Density: 1.514g/cm³
Vapor Pressure: 7.59E-21mmHg at 25°C
PKA: 3.15±0.10(Predicted)
PSA: 140.31000
LogP: 0.40980

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