59288-38-9

Basic information

• Product Name: 5-HYDROXY-NICOTINIC ACID ETHYL ESTER
• Synonyms: 5-Hydroxypyridine-3-carboxylic acid ethyl ester;3-(Ethoxycarbonyl)-5-hydroxypyridine;3-Pyridinecarboxylic acid, 5-hydroxy-, ethyl ester;Ethyl 5-hydroxy-3-pyridinecarboxylate;ethyl 5-hydroxypyridine-3-carboxylate;Ethyl 5-hydroxypyridine-3-carboxylate, 3-(Ethoxycarbonyl)-5-hydroxypyridine;5-hydroxy-3-pyridinecarboxylic acid ethyl ester
• CAS NO: 59288-38-9
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.162
• Mol File: 59288-38-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 375.4 °C at 760 mmHg
• Flash Point: 180.8 °C
• Appearance: /
• Density: 1.233 g/cm³
• Vapor Pressure: 3.61E-06mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: 5-HYDROXY-NICOTINIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-NICOTINIC ACID ETHYL ESTER(59288-38-9)
• EPA Substance Registry System: 5-HYDROXY-NICOTINIC ACID ETHYL ESTER(59288-38-9)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 59288-38-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

InChI:InChI=1/C8H9NO3/c1-2-12-8(11)6-3-7(10)5-9-4-6/h3-5,10H,2H2,1H3

Upstream product

• 27828-71-3 5-hydroxynicotinic acid 
• 556-52-5 oxiranyl-methanol 
• 20825-98-3 5-chloro-nicotinic acid ethyl ester 
• 64-17-5 ethanol 

Downstream Products

• 112193-39-2 5-hydroxynicotinic acid hydrazide 
• 101512-21-4 5-hydroxypyridine-3-carboxamide 
• 263270-34-4 5-(benzyloxy)nicotinic acid 
• 122535-03-9 ethyl furo[3,2-b]pyridine-6-carboxylate 
• 59288-40-3 ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate 
• 112193-35-8 nooglutil 
• 115374-93-1 4-[(5-Hydroxy-pyridine-3-carbonyl)-amino]-butyric acid 

Relevant articles and documents

A highly efficient solution and solid state ESIPT fluorophore and its OLED application

We present herein the synthesis and photophysics of 2,2′-bipyridine-3,3′-diol-5,5′-dicarboxylic acid ethyl ester (BP(OH)2DCEt2), an excited state intramolecular proton transfer (ESIPT)-based fluorophore featuring two identical intramolecular hydrogen bonds. BP(OH)2DCEt2emits efficiently not only in solution, including protic solvents (λem= 521 nm,Φf= 40 to 75%), but also in crystalline state (λem= 530 nm,Φf= 51%). In addition, its saponified form (Na2BP(OH)2DC) is highly fluorescent in water (λem= 490 nm,Φf= 51%). Finally, the good electroluminescence performance of BP(OH)2DCEt2is also demonstrated in an OLED device.

A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure

A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.

NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS

The invention is related to compound which comprises at least one radical C=Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C=Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.