59288-38-9Relevant academic research and scientific papers
A highly efficient solution and solid state ESIPT fluorophore and its OLED application
Trannoy, Virgile,Léaustic, Anne,Gadan, Sophie,Guillot, Régis,Allain, Clémence,Clavier, Gilles,Mazerat, Sandra,Geffroy, Bernard,Yu, Pei
, p. 3014 - 3021 (2021)
We present herein the synthesis and photophysics of 2,2′-bipyridine-3,3′-diol-5,5′-dicarboxylic acid ethyl ester (BP(OH)2DCEt2), an excited state intramolecular proton transfer (ESIPT)-based fluorophore featuring two identical intramolecular hydrogen bonds. BP(OH)2DCEt2emits efficiently not only in solution, including protic solvents (λem= 521 nm,Φf= 40 to 75%), but also in crystalline state (λem= 530 nm,Φf= 51%). In addition, its saponified form (Na2BP(OH)2DC) is highly fluorescent in water (λem= 490 nm,Φf= 51%). Finally, the good electroluminescence performance of BP(OH)2DCEt2is also demonstrated in an OLED device.
A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure
Kiselev,Machula,Efimov,Pashkova,Stovbun
, p. 615 - 619 (2019/07/17)
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
Synthesis method for 4-(tert-butoxycarbonyl) octahydrofuro[3,2-b] pyridine-6-carboxylic acid
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Paragraph 0008; 0009, (2016/12/16)
The present incention relates to a synthesis method for 4-(tert-butoxycarbonyl) octahydrofuro[3,2-b] pyridine-6-carboxylic acid, and mainly solves the technical problem of no synthesis method suitable for industrialization at present. The synthesis method comprises six steps: first esterifying a compound 1 to obtain a compound 2; then performing iodination to produce a compound 3; acetylating the compound 3 to obtain a compound 4; then performing coupling to obtain a compound 5; performing cyclization to obtain a compound 6; performing hydrogenation to obtain a compound 7, then reacting with Boc anhydride to obtain a compound 8; and performing hydrogenation to obtain a final compound 9. The reaction formula is shown in the description.
NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS
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Page/Page column 115-116, (2008/06/13)
The invention is related to compound which comprises at least one radical C=Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C=Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.
New 8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them
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, (2008/06/13)
New 8-substituted nucleoside and purine derivatives of the general formula: STR1 wherein R represents an amino group or an hydroxy group possibly in the corresponding keto tautomeric form, R1 is hydrogen or an amino group, R2 is hydrogen or a β-D-ribofuranosyl radical wherein the primary hydroxy group and/or the two secondary hydroxy groups may be derivatized, R3 is an optionally substituted aryl or monocyclic heteroaryl radical and, X is --O-- or --S--. The new compounds have antihyperlipaemic activity.
