- TRPML MODULATORS
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The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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Paragraph 0746
(2021/06/26)
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- 11C-LABELED BENZYL-LACTAM COMPOUNDS AND THEIR USE AS IMAGING AGENTS
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The invention relates to ""C-labeled compounds, their preparation, compositions comprising an effective amount of a ""C-labeled compound, and the use of a ""C-labeled compound as a radiopharmaceutical for positron emission tomography.
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Page/Page column 23
(2008/06/13)
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- NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES
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The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula (I) wherein R1 is a group of the formula G1 or G2 depicted below, wherein R1, R3, R6, R13, X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.
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Page/Page column 30-31
(2008/06/13)
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- A Novel Two-Step Synthesis of Hexahydropyrazinoquinolines
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The hexahydropyrazinoquinolines 2 were prepared in good yields by reaction of 2-(4-substituted 1-piperazinyl)benzaldehydes 5 with malononitrile and subsequent thermal cyclization of the condensation products 6; the latter reaction takes place via a
- Nijhuis, Walter H. N.,Verboom, Willem,Reinhoudt, David N.
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p. 641 - 645
(2007/10/02)
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