112297-79-7

Basic information

• Product Name: Deoxy Arteether
• Synonyms: (2S,3R,3aS,6R,6aS,9S,10aR,10bR)-2-Ethoxydecahydro -3,6,9-trimethyl-0aH-9,10b-Epoxypyrano[4,3,2-jk][2]benzoxepin;Chemal 331;Deoxy Arteether;Desoxyarteether A
• CAS NO: 112297-79-7
• Molecular Formula: C17H28O4
• Molecular Weight: 296.40182
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 112297-79-7.mol

Chemical Properties

• Melting Point: 68-70?C
• Appearance: /
• Refractive Index: 1.516
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: Deoxy Arteether(CAS DataBase Reference)
• NIST Chemistry Reference: Deoxy Arteether(112297-79-7)
• EPA Substance Registry System: Deoxy Arteether(112297-79-7)

Safety Data

• Hazardous Substances Data: 112297-79-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Deoxy Arteether is used as an antimalarial agent for its ability to effectively treat malaria infections. It is a valuable component in the development of new antimalarial drugs due to its potent activity against the Plasmodium parasite responsible for causing the disease.
Used in Research and Development:
Deoxy Arteether is used as a research compound for studying the mechanisms of action and potential applications of Artemisinin and its derivatives in the treatment of various diseases, including malaria. Its unique chemical properties and biological activity make it an important tool in the ongoing search for new and improved therapies.

InChI:InChI=1/C17H28O4/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1

Upstream product

• 71939-50-9 dihydroartemisinin 
• 63968-64-9 C₁₂H₁₃O₂(CH₃)3(O)(OO) 
• 75887-54-6 artemotil 

Relevant articles and documents

Arteether, a new antimalarial drug: Synthesis and antimalarial properties

Arteether (6) has been prepared from dihydroqinghaosu (3) by etherification with ethanol in the presence of Lewis acid and separated from its chromatographically slower moving α-dihydroqinghaosu ethyl ether (7). The absolute stereochemistry at C-12 has been determined by 1H NMR data (J11,12, NOESY). Ethyl ethers 6 and 7 showed potent in vitro inhibition of Plasmodium falciparum, and both compounds were highly potent antimalarials in mice infected with a drug-sensitive strain of Plasmodium berghei. Crystalline arteether (6) and its oily epimer 7 were 2-3 times more potent schizontocides than qinghaosu (1), but deoxy compounds 8, 9, and 11 were 100-300 times less potent in vitro than their corresponding peroxy precursors. Pharmacological studies have shown arteether (6) to have antimalarial activity in animals comparable to artesunate (2) and artemether (4), both of which are fast-acting blood schizontocides in humans. Arteether (6) has now been chosen for a clinical evaluation in high-risk malaria patients.