75887-54-6 Usage
Description
Arteether reached the market in the Netherlands as a solution in sesame oil,
administered by i.m. injection, for the treatment of severe malaria infections in children and
adolescents. Artheether, a sesquiterpene acetal with an endoperoxide bridge, is an ether
derivative of the naturally occuring compound artemisinin, the active component of
Chinese herbal remedies. As the other structural analogs of artemisinin, such as
artesunate or artemether, it acts rapidly against Plasmodium, the parasite responsible for
the disease, during the early blood stage of its development. It also exhibits a
gametocytocidal activity against Plasmodium falciparum, reducing its potential for
transmission. Because the only controlled clinical studies had been performed in children
and adolescents, this new antimalarial drug was only approved for young patients. Further
studies in adults treated with 150 mg i.m. artemotil, once daily for three consecutive days,
indicated that the drug was efficient, rapidly acting (parasite clearance time meanly 38 h)
and well tolerated. A new promising achievement in the regression of malaria is the
combination of artemisinin derivatives with other long-lived antimalarials as mefloquine or
pyrimethamine/sulfa.
Chemical Properties
White Crystalline Solid
Uses
Derivative of Artemisinin. Antimalarial
Brand name
Artemotil
Check Digit Verification of cas no
The CAS Registry Mumber 75887-54-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,8 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75887-54:
(7*7)+(6*5)+(5*8)+(4*8)+(3*7)+(2*5)+(1*4)=186
186 % 10 = 6
So 75887-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14?,15-,16-,17-/m1/s1
75887-54-6Relevant articles and documents
Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
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, (2015/02/02)
The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.
New method for the synthesis of ether derivatives of artemisinin
Bora, Pranjal P.,Baruah, Nabajyoti,Bez, Ghanashyam,Barua, Nabin C.
, p. 1218 - 1225 (2012/04/04)
Dihydroartemisinin can be converted to its ether derivatives in good yields by reaction with different alcohols in the presence of a catalytic amount of dodecatungstophosphoric acid hydrate. Easy handling, trouble-free workup by filtration, excellent yields, and very short reaction times are some of the highlights of this protocol. Copyright Taylor & Francis Group, LLC.
PREPARATIVE PROCESS FOR ETHER DERIVATIVE OF ARTEMISININ
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Page/Page column 11; 12; 14; 15, (2008/12/07)
The present invention relates to a process for synthesis of ether derivative of artemisinin by reducing artemisinin to dihydroartemisinin using a mixture of sodium borohydride and a dihydroxy compound, followed by etherification in presence of an acid catalyst and an alcohol.
