112342-71-9Relevant articles and documents
HMOX1 inducers
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, (2020/09/18)
The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.
TRANSFORMATIONS OF 1,2,4-THIADIAZOLO/2,3-x/AZINES
Koren, Bozidar,Stanovnik, Branko,Tisler, Miha
, p. 689 - 697 (2007/10/02)
Hydrolysis of 1,2,4-thiadiazolo/2,3-c/pyrimidine derivative 2 produced cyanoaminopyrimidine 4, while treatment of 1,2,4-thiadiazolo/2,3-b/pyridazine 5 with hydrazine hydrate gave thiourea derivative 7. 1,2,4-Thiadiazolo/2,3-a/pyridine 8 and 1,2,4-thiadiazolo/2,3-a/pyrazine 9 gave by alkaline hydrolysis the corresponding pyridopyrimidine 10 and pteridine 11, respectively.The compound 10 was converted with phenacyl bromide into 14 and further cyclized in PPA into pyrido/2,3-d/thiazolo/2,3-a/pyrimidine 15.Pyrazinylthiourea derivative 16 was cyclized in acidic solution into thiazolo/4,5-b/pyrazine 17, which was converted by hydrolysis and decarboxylation into amino derivative 20.This gave with ethyl acetoacetate pyrazino/2',3':4,5/thiazolo/3,2-a/pyrimidine 23. 1,2,4-Thiadiazoloazines 24 and N-ethoxycarbonyl-N'-azinylthioureas 25 were transformed with hydrogen peroxide into urea derivatives 26.