112399-50-5

Basic information

• Product Name: 2-Bromo-5-fluorobenzyl bromide
• Synonyms: 1-Bromo-2-(bromomethyl)-4-fluorobenzene;5-FLUORO-2-BROMOBENZYL BROMIDE;2-BROMO-5-FLUOROBENZYL BROMIDE;2-Bromo-5-fluorobenzyl bromide 95%;2-Bromo-5-fluorobenzylbromide95%;Bromofluorobenzylbromide 25---;2-BroMo-5-fluorobenl broMide;1-Bromo-2-(bromomethyl)-4-fluorobenzene, alpha,2-Dibromo-5-fluorotoluene
• CAS NO: 112399-50-5
• Molecular Formula: C₇H₅Br₂F
• Molecular Weight: 267.92
• EINECS: -0
• Product Categories: Fluorine series;alkyl bromide| alkyl Fluorine
• Mol File: 112399-50-5.mol

Chemical Properties

• Melting Point: 34-35°C
• Boiling Point: 89-90°C 1mm
• Flash Point: 89-90°C/1mm
• Appearance: /
• Density: 1.923 g/cm³
• Vapor Pressure: 0.045mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• Water Solubility: Difficult to mix in water.
• Sensitive: Lachrymatory
• BRN: 4177658
• CAS DataBase Reference: 2-Bromo-5-fluorobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorobenzyl bromide(112399-50-5)
• EPA Substance Registry System: 2-Bromo-5-fluorobenzyl bromide(112399-50-5)

Safety Data

• Hazard Codes: C,Xn
• Statements: 34-36-52-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 112399-50-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-5-fluorobenzyl bromide is used as a key intermediate in the synthesis of Benzazepines, a class of compounds with potential therapeutic applications. The alkylation of the β-amino ester 1a with 2-bromo-5-fluorobenzyl bromide results in the formation of Benzazepines as a white solid after purification through silica gel chromatography. This process highlights the importance of 2-Bromo-5-fluorobenzyl bromide in the development of new pharmaceutical agents.

InChI:InChI=1/C7H5Br2F/c8-4-5-3-6(10)1-2-7(5)9/h1-3H,4H2

Upstream product

• 452-63-1 2-Bromo-5-fluorotoluene 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 6942-39-8 methyl 2-bromo-5-fluorobenzoate 

Downstream Products

• 127792-49-8 2-(2-bromo-5-fluorophenyl)acetonitrile 
• 170927-05-6 4-bromo-7-fluoro-2-methylindan-1-one 
• 1312954-51-0 N-(2-bromo-5-fluorobenzyl)hydrazinothiocarbamide 
• 1367501-01-6 C₁₄H₁₃BrFNO₅ 
• 1367421-95-1 C₉H₁₀BrFO₂ 
• 1619256-36-8 4-fluoro-2-(2-methylallyl)benzaldehyde 

Relevant articles and documents

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