394-28-5

Basic information

• Product Name: 2-Bromo-5-fluorobenzoic acid
• Synonyms: 2-Bromo-5-fluorobenz;2-BroMo-5-fluorobenzoic Acid, 97+%;2-bromo-5-fluorobenzoicacid,98%;RARECHEM AL BO 0747;BUTTPARK 19\01-66;2-BROMO-5-FLUOROBENZOIC ACID;2-Bromo-5-Fluorobenzoic;2-Bromo-5-fluorobenzoic acid 98%
• CAS NO: 394-28-5
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.0078632
• EINECS: -0
• Product Categories: intermediate;Fluorin-contained Benzoic acid series;FINE Chemical & INTERMEDIATES;blocks;Bromides;Carboxes;FluoroCompounds;Acids and Derivatives;Halides;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Miscellaneous;Acids & Esters;Bromine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series
• Mol File: 394-28-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 154-157 °C(lit.)
• Boiling Point: 291.1 °C at 760 mmHg
• Flash Point: 129.8 °C
• Appearance: white to light yellow crystal powder
• Density: 1.789 g/cm³
• Vapor Pressure: 0.000915mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.51±0.10(Predicted)
• BRN: 2575978
• CAS DataBase Reference: 2-Bromo-5-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-fluorobenzoic acid(394-28-5)
• EPA Substance Registry System: 2-Bromo-5-fluorobenzoic acid(394-28-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 394-28-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H4BrFO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 352-70-5 m-Fluorotoluene 
• 452-63-1 2-Bromo-5-fluorotoluene 

Downstream Products

• 313547-14-7 2-bromo-5-fluoro-N-methoxy-N-methylbenzamide 
• 477932-69-7 C₁₂H₁₄FNO₂ 
• 709042-33-1 5-fluoro-2-(3-methylbutylamino)benzoic acid 
• 1094467-32-9 2-bromo-N-cyclopropyl-5-fluoro-N-methylbenzamide 
• 1400638-95-0 (4S)-4,5-dihydro-2-(5′-fluoro-2′-(diphenylphosphino)phenyl)-4-isopropyloxazole 
• 1400638-90-5 (4S)-4,5-dihydro-2-(5′-fluoro-2′-bromophenyl)-4-isopropyloxazole 
• 1358761-74-6 C₁₃H₉BrF₂N₂O 
• 1241898-42-9 (2-bromo-5-fluorophenyl)(1-methylpiperidin-4-yl)methanone 
• 1312954-51-0 N-(2-bromo-5-fluorobenzyl)hydrazinothiocarbamide 
• 1312954-50-9 1-bromo-4-fluoro-2-(isothiocyanatomethyl)benzene 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 1221746-47-9 2-((2-carboxy-4-fluorophenyl)amino)-3-methoxybenzoic acid 
• 1187889-56-0 N-biphenyl-4-yl-3-[4-(2-bromo-5-fluoro-benzoyl)-piperazin-1-yl]-3-oxo-propionamide 
• 1119087-12-5 5-fluoro-2-(6-(2-(trifluoromethyl)phenyl)pyridin-3-ylamino)benzoic acid 

Relevant articles and documents

Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light could in situ form a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry. This journal is

TEMPO-mediated oxidation of primary alcohols to aldehydes under visible light and air

A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant. Ru(bpy)3(PF 6)2 (bpy: bipyridyl) and Ir(dtb-bpy)(ppy) 2(PF6) (dtb-bpy: 4,4′-di-tert-butyl-2,2′- bipyridyl; ppy: 2-phenylpyridine) were used as the sensitizers. A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed. Molecular oxygen from air was the terminal oxidant. Copyright

Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines

Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.