- Synthetic studies of fisetin, myricetin and nobiletin analogs and related probe molecules
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We synthesized a series of analogs of fisetin, myricetin and nobiletin, as well as related fluorescein- and biotin-based flavone-probe molecules, on a suitable scale for biological and structure-activity relationship studies.
- Hiza, Aiki,Tsukaguchi, Yuta,Ogawa, Takahiro,Inai, Makoto,Asakawa, Tomohiro,Hamashima, Yoshitaka,Kan, Toshiyuki
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p. 1371 - 1396
(2016/10/12)
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- Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
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A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro
- Oshitari, Tetsuta,Okuyama, Yuji,Miyata, Yoshiki,Kosano, Hiroshi,Takahashi, Hideyo,Natsugari, Hideaki
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p. 4540 - 4544
(2011/09/12)
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- Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones
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A series of 3′-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition
- Quintin, Jerome,Buisson, Didier,Thoret, Sylviane,Cresteil, Thierry,Lewin, Guy
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scheme or table
p. 3502 - 3506
(2010/04/26)
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- Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines
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Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
- Li, Shiming,Pan, Min-Hsiung,Lai, Ching-Shu,Lo, Chih-Yu,Dushenkov, Slavik,Ho, Chi-Tang
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p. 3381 - 3389
(2008/02/07)
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