112448-39-2

Usage

Uses

Used in Pharmaceutical Industry:
3'-Demethylnobiletin is used as a therapeutic agent for its anti-inflammatory properties, aiming to alleviate inflammation-related conditions and promote healing.
Used in Oncology:
3'-Demethylnobiletin is utilized as an anti-cancer agent, targeting various types of cancer by modulating signaling pathways that regulate cell growth and proliferation, thus potentially inhibiting tumor development and progression.
Used in Neuroprotection:
3'-Demethylnobiletin is employed as a neuroprotective agent, supporting the health of the nervous system and potentially reducing the risk of neurodegenerative diseases by combating oxidative stress and inflammation.
Used in Metabolic Health Improvement:
3'-Demethylnobiletin is used as a metabolic health enhancer, contributing to the regulation of glucose and lipid metabolism, which may help in managing and reducing the risk of chronic conditions such as diabetes and cardiovascular diseases.
Used in Nutraceutical Industry:
3'-Demethylnobiletin is incorporated into dietary supplements and functional foods for its overall health-promoting effects, including its antioxidant and anti-inflammatory properties, to support general well-being and prevent various diseases.

InChI:InChI=1/C20H20O8/c1-23-13-7-6-10(8-11(13)21)14-9-12(22)15-16(24-2)18(25-3)20(27-5)19(26-4)17(15)28-14/h6-9,21H,1-5H3

Upstream product

• 29201-99-8 3'-benzyloxy-4',5,6,7,8-pentamethoxyflavone 
• 112448-40-5 3'-benzyloxy-4',5,6,7,8-pentamethoxyflavanone 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 1120350-51-7 C₂₀H₂₂O₈ 
• 1322640-35-6 C₂₇H₂₈O₉ 
• 1322640-36-7 C₂₇H₂₈O₉ 
• 14786-40-4 1-(2,3,4,5,6-pentamethoxyphenyl)ethan-1-one 
• 91556-09-1 2,3,4,5,6-pentamethoxybenzoic acid 
• 92157-76-1 methyl 2,3,4,5,6-pentamethoxybenzoate 
• 7169-08-6 2,3,4,5,6-Pentamethoxy-benzoylchlorid 
• 58452-00-9 3-benzyloxy-4-methoxybenzoic acid 

Downstream Products

• 29202-00-4 3',5-dihydroxy-4',6,7,8-tetramethoxyflavone 

Relevant academic research and scientific papers

Synthetic studies of fisetin, myricetin and nobiletin analogs and related probe molecules

We synthesized a series of analogs of fisetin, myricetin and nobiletin, as well as related fluorescein- and biotin-based flavone-probe molecules, on a suitable scale for biological and structure-activity relationship studies.

Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production

A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro

Semisynthesis and antiproliferative evaluation of a series of 3′-aminoflavones

A series of 3′-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition

Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.