112571-69-4

Basic information

• Product Name: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT
• Synonyms: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT;D-INS 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT;INS(1,4,5)P3 3NH3;D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE TRIAMMONIUM SALT
• CAS NO: 112571-69-4
• Molecular Formula: C₆H₉O₁₅P₃*6H₄N
• Molecular Weight: 471.19
• Mol File: 112571-69-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT(112571-69-4)
• EPA Substance Registry System: D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT(112571-69-4)

Safety Data

• Hazardous Substances Data: 112571-69-4(Hazardous Substances Data)

Usage

Uses

Used in Cellular Signaling Research:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT is used as a research tool for studying cellular signaling pathways, specifically those involving calcium release from intracellular stores. Its ability to induce Ca2+ release makes it a valuable compound for understanding the complex mechanisms of cellular communication and response to various stimuli.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT is used as a potential therapeutic agent for conditions related to calcium signaling dysregulation. By modulating intracellular calcium levels, it may contribute to the development of treatments for various diseases and disorders.
Used in Analytical Chemistry:
D-MYO-INOSITOL 1,4,5-TRISPHOSPHATE TRIAMMONIUM SALT is also utilized in analytical chemistry as a reference compound for the development and validation of analytical methods and techniques related to the detection and quantification of inositol phosphates and other related compounds in biological samples.

Upstream product

• 112489-44-8 C₃₀H₃₁Br₂O₁₆P₃ 
• 96533-43-6 2,3-cyclopentylidene-myo-inositol 
• 112489-41-5 rac. 2,3-O-cyclopentylidine-6-O-(2,7-dibromo-9-phenylxanthen-9-yl)-myo-inositol 
• 34361-60-9 1,2:4,5-dicyclohexylidene-myo-inositol 
• 35949-66-7 (+/-)-1,4-di-O-benzyl-2,3-O-cyclohexylidene-myo-inositol 
• 104873-73-6 1L-5,6-di-O-allyl-1,4-di-O-benzyl-myo-inositol 
• 98925-52-1 (+/-)-5,6-di-O-allyl-1,4-di-O-benzyl-myo-inositol 
• 116096-45-8 C₂₈H₃₆O₈ 
• 13035-66-0 C₂₆H₃₂O₆ 
• 6763-49-1 (±)-1,2:3,4-di-O-cyclohexylidene-myo-inositol 
• 6763-49-1 (+/-)-1,2:5,6-dicyclohexylidene-myo-inositol 
• 87-89-8 D-myo-inositol 
• 115510-58-2 (+)-1D-2,5,6-tri-O-benzyl-1,3,4-tris(dibenzylphospho)-myo-inositol 
• 104873-74-7 1D-1,4,5-tri-O-allyl-3,6-di-O-benzyl-myo-inositol 

Relevant articles and documents

A chemoenzymatic synthesis of D-myo-inositol 1,4,5-trisphosphate

Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1).A new practical route has been developed for the synthesis of D-myo-inositol 1,4,5-trisphosphate starting from D-1 via selective acylation of the 6-hydroxyl group.

Synthesis and Some Properties of D-myo-Inositol 1,4,5-Tris(dihydrogen phosphate)

Optically active myo-inositol 1,4,5-tris(dihydrogen phosphate) 1, which has now been recognized as a second messenger in a new intracellular signal transduction system, has been prepared starting from myo-inositol.The key step, phosphorylation of an adequately protected polyhydroxy derivative, was accomplished by three methods, among which a phosphoramidite method using a new phosphitylating agent, o-xylylene N,N-diethylphosphoramidite, gave the triphosphoric ester in quantitative yield.Optical resolution was effectively realized by derivatization into diastereoisomeric l-menthoxyacetic esters.NMR spectra and optical rotation are shown to depend on the pH of an aqueous solution of compound 1.

Synthesis of Optically Active myo-Inositol 1,3,4-Triphosphate

Synthesis of optically active myo-inositol 1,3,4-triphosphate has been accomplished.Efficiency of a chiral HPLC column for optical resolution of myo-inositols is shown.

SYNTHESIS OF D-myo-INOSYTOL 1,4,5-TRIPHOSPHATE

The conversion of myo-inositol into the ammonium salts both of racemic and enantiomerically pure D-myo-inositol 1,4,5-triphosphate (6) is described.The n.m.r. spectroscopic properties and biological activity of synthetic and naturally-isolated (6) are virtually identical.