112584-40-4

Basic information

• Product Name: 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE
• Synonyms: 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE;2-Bromo-5-methoxybenzohydrazide;2-Bromo-5-methoxybenzoic acid hydrazide
• CAS NO: 112584-40-4
• Molecular Formula: C₈H₉BrN₂O₂
• Molecular Weight: 245.07
• Mol File: 112584-40-4.mol

Chemical Properties

• Melting Point: 165 °C
• Appearance: /
• Density: 1.559 g/cm³
• Refractive Index: 1.591
• Storage Temp.: Store Cold
• PKA: 11.48±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE(112584-40-4)
• EPA Substance Registry System: 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE(112584-40-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 112584-40-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE is used as a building block in organic synthesis for the creation of new molecules with potential biological activity. Its unique structure and functional groups allow it to undergo a range of chemical reactions, making it a valuable component in the synthesis of complex compounds.
Used in Pharmaceutical Research:
In Pharmaceutical Research, 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE is utilized as a precursor for the synthesis of pharmaceutical compounds. Its reactivity and structural features contribute to the development of new drugs with potential therapeutic applications.
Used in Dye and Pigment Production:
2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE is also used in the production of dyes and pigments due to its aromatic nature and potential reactivity. Its chemical properties make it suitable for creating colorants used in various industries, such as textiles, plastics, and printing inks.
Used in Chemical Reactions:
Due to its structure and functional groups, 2-BROMO-5-METHOXYBENZENE-1-CARBOHYDRAZIDE has the potential to undergo various chemical reactions, making it a versatile compound in the field of chemistry. It can serve as a precursor for the synthesis of more complex compounds, contributing to the advancement of chemical research and development.

InChI:InChI=1/C8H9BrN2O2/c1-13-5-2-3-7(9)6(4-5)8(12)11-10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 35450-36-3 methyl 2-bromo-5-methoxybenzoate 
• 58733-41-8 5-methoxy-2-bromo benzoic acid ethyl ester 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 

Downstream Products

• 286440-10-6 1-(2-bromo-5-methoxybenzoyl)thiosemicarbazide 
• 1226513-70-7 2-bromo-5-methoxybenzoic acid (4-chloro-2-hydroxybenzylidene)hydrazide 
• 1226514-00-6 2-bromo-5-methoxybenzoic acid (2-hydroxy-3,5-dinitrobenzylidene)hydrazide 
• 1226513-78-5 2-bromo-5-methoxybenzoic acid (5-tert-butyl-2-hydroxybenzylidene)hydrazide 
• 1256575-02-6 (E)-N'-(3-(3,5,6-trichloropyridin-2-yloxy)benzylidene)-2-bromo-5-methoxybenzohydrazide 
• 1220286-51-0 N-[4-[[(6-chloro-3-pyridinyl)methyl]ethylamino]-3-methyl-5-nitro-1,2,3,6-tetrahydropyrimidin-1-yl]-2-bromo-5-methoxybenzamide 

Relevant articles and documents

Synthesis of some bioactive 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives

Eight novel 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and th

Copper-Catalyzed Cascade Synthesis of [1,2,4]-Triazoloquinazolinones

An efficient and practical method for the synthesis of 1,2,4-triazolo[5,1- b ]quinazolin-9(3 H)-ones has been developed via the copper-catalyzed domino reactions of readily available substituted N ′-acetyl-2-bromobenzohydrazides with cyanamide. The protocol uses inexpensive CuI as the catalyst, and no other ligand or additive was required. The target products were prepared in good to excellent yields with tolerance of various functional groups.

An integration of condensation/Ullmann-type coupling/bicyclization sequences: Copper-catalyzed three-component direct synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones

A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.

Synthesis, characterization, and biological evaluation of some N-aryl hydrazones and their 2,3-disubstituted-4-thiazolidinone derivatives

A series of 2,3-disubstituted 4-thiazolidinones 6 and 8a-p have been prepared by the cyclo condensation reaction of various substituted N-aryl hydrazones 5 and 7a-p with mercapto acetic acid. The intermediate N-aryl hydrazones 5 and 7a-p were synthesized

Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b] [1,3,4]thiadizoles (5a-j) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4- b][1,3,4]thiadizoles (7a-j) were prepared. In continuation of a previously reported study, the firs

The one step synthesis of 2-(2-bromo-5-methoxyphenyl)-5-(3-arylidene)-1,3- thiazolo[3,2-b ]-1,2,4-triazol-6-(5H)-ones and the evaluation of the anticonvulsant activity

A smooth one-step synthesis of 2-(2-bromo-5-methoxyphenyl)-5-(3-arylidene)- 1,3-thiazolo[3,2- b ]-1,2,4-triazol-6-(5 H )-ones (4a-n) is described. The newly prepared compounds are characterized by analytical and IR, 1 H NMR, 13 C NMR, and FABMS spectral a

Process improvements for the preparation of kilo quantities of a series of isoindoline compounds

A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorder. The isoindoline compounds were prepared by reduction of the corresponding phthalimides with LiAlH4. One compound was not chiral, and the other two required an enantioselective synthesis. The key step for these optically active analogues involved the coupling by an SN2 process of either a piperazynyl intermediate or a piperdinyl intermediate with methyl 3-benzyloxy-2-trifluoromethansulfonatopropionate. The products for these two analogues had >98% ee. Process improvements led to the multi-kilogram syntheses of each of these compounds.