2-Bromo-5-methoxybenzohydrazide

Base Information

• Chemical Name: 2-Bromo-5-methoxybenzohydrazide
• CAS No.: 112584-40-4
• Molecular Formula: C8H9BrN2O2
• Molecular Weight: 245.076
• Hs Code.: 2928000090
• European Community (EC) Number: 630-231-8
• DSSTox Substance ID: DTXSID10384121
• Wikidata: Q82176066
• Mol file: 112584-40-4.mol

Synonyms:2-bromo-5-methoxybenzohydrazide;112584-40-4;2-Bromo-5-methoxybenzene-1-carbohydrazide;Maybridge1_001538;SCHEMBL9778317;HMS545N20;2-bromo-5-methoxy benzohydrazide;DTXSID10384121;CCG-44985;MFCD00117528;AKOS000177093;AS-9986;CS-0257990;FT-0727706;EN300-68752;A802608;J-508392;METHYL3-(2-METHOXYPHENYL)-2-PHENYLACRYLATE;SR-01000634782-1

Chemical Property of 2-Bromo-5-methoxybenzohydrazide

Chemical Property:

• Melting Point: 165 °C
• Refractive Index: 1.591
• PKA: 11.48±0.10(Predicted)
• PSA: 64.35000
• Density: 1.559 g/cm³
• LogP: 2.15240
• Storage Temp.: Store Cold
• Sensitive.: Air Sensitive
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.98474
• Heavy Atom Count: 13
• Complexity: 189

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-methoxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)Br)C(=O)NN

Technology Process of 2-Bromo-5-methoxybenzohydrazide

There total 3 articles about 2-Bromo-5-methoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-bromo-5-methoxybenzoate (35450-36-3) → 2-bromo-5-methoxy-benzoic acid hydrazide (112584-40-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2012.02.030

Reference yield: 78.0%

5-methoxy-2-bromo benzoic acid ethyl ester (58733-41-8) → 2-bromo-5-methoxy-benzoic acid hydrazide (112584-40-4)

Guidance literature:

With hydrazine; In ethanol; at 78 ℃; for 8.5h; Large scale;

DOI:10.1021/op020225p

Reference yield:

2-bromo-5-methoxy-benzoic acid (22921-68-2) → 2-bromo-5-methoxy-benzoic acid hydrazide (112584-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / ethanol / 20 h / Reflux; Large scale

2: hydrazine / ethanol / 8.5 h / 78 °C / Large scale

With sulfuric acid; hydrazine; In ethanol;

DOI:10.1021/op020225p

upstream raw materials:

methyl 2-bromo-5-methoxybenzoate

5-methoxy-2-bromo benzoic acid ethyl ester

2-bromo-5-methoxy-benzoic acid

Downstream raw materials:

α-chloro-2-bromo-5-methoxybenzaldehyde-2-phenylsulfonylhydrazone

4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Refernces

• 1、 Lou, Zhenbang,Man, Ningning,Yang, Haijun,Zhu, Changjin,Fu, Hua. "Copper-Catalyzed Cascade Synthesis of [1,2,4]-Triazoloquinazolinones". supporting information. p. 1395 - 1399. Retrieved 2018/05/03.
• 2、 Nandagokula, Chidananda,Poojary, Boja,Vittal, Sumangala,Shenoy, Shalini,Shetty, Prashanth,Tangavelu, Arulmoli. "Synthesis, characterization, and biological evaluation of some N-aryl hydrazones and their 2,3-disubstituted-4-thiazolidinone derivatives". . p. 253 - 266. Retrieved 2013/03/13.