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Pyridazine-3-carboxylic acid ethyl ester, with the molecular formula C8H8N2O2, is an ester derived from pyridazine-3-carboxylic acid, a heterocyclic compound. This versatile chemical compound is widely used in organic synthesis and pharmaceutical research, serving as a key building block for the synthesis of various pharmaceutical compounds. Its applications extend to the production of herbicides, insecticides, and other agrochemicals, making it a valuable compound for chemical research and development.

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  • 1126-10-9 Structure
  • Basic information

    1. Product Name: Pyridazine-3-carboxylic acid ethyl ester
    2. Synonyms: Pyridazine-3-carboxylic acid ethyl ester;3-Pyridazinecarboxylicacid,ethylester(7CI,8CI,9CI);ethyl pyridazine-3-carboxylate;ethyl 3-pyridazinecarboxylate
    3. CAS NO:1126-10-9
    4. Molecular Formula: C7H8N2O2
    5. Molecular Weight: 152.15062
    6. EINECS: N/A
    7. Product Categories: GLYCINESCAFFOLD
    8. Mol File: 1126-10-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: Pyridazine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Pyridazine-3-carboxylic acid ethyl ester(1126-10-9)
    11. EPA Substance Registry System: Pyridazine-3-carboxylic acid ethyl ester(1126-10-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1126-10-9(Hazardous Substances Data)

1126-10-9 Usage

Uses

Used in Pharmaceutical Research:
Pyridazine-3-carboxylic acid ethyl ester is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, Pyridazine-3-carboxylic acid ethyl ester is employed as a versatile intermediate for the preparation of a wide range of organic compounds. Its ability to undergo various chemical reactions allows for the creation of diverse molecules with different properties and applications.
Used in Agrochemical Production:
Pyridazine-3-carboxylic acid ethyl ester is used in the production of herbicides, insecticides, and other agrochemicals. Its incorporation into these products contributes to their effectiveness in controlling pests and promoting crop growth, thereby enhancing agricultural productivity.
Used in Chemical Research and Development:
As a valuable compound for chemical research and development, Pyridazine-3-carboxylic acid ethyl ester is utilized in the exploration of new chemical reactions, synthesis methods, and potential applications. Its unique properties and reactivity make it an essential tool for researchers in the field of chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1126-10-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1126-10:
(6*1)+(5*1)+(4*2)+(3*6)+(2*1)+(1*0)=39
39 % 10 = 9
So 1126-10-9 is a valid CAS Registry Number.

1126-10-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl pyridazine-3-carboxylate

1.2 Other means of identification

Product number -
Other names Pyridazin-3-carbonsaeure-ethylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1126-10-9 SDS

1126-10-9Relevant articles and documents

ATG7 INHIBITORS AND THE USES THEREOF

-

Paragraph 00397, (2018/05/27)

Disclosed are chemical entities which are compounds of formula (I) : or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.

Synthesis and antiviral activity of thiosemicarbazone derivatives of pyridazinecarbaldehydes and alkyl pyridazinyl ketones

Easmon,Heinisch,Holzer,Rosenwirth

, p. 1196 - 1201 (2007/10/02)

Various novel thiosemicarbazones (TSCs) 15b-e, 16b-e, 17b-e, 18b-e, and 19b-e derived from 4-pyridazinecarbaldehyde, 3-pyridazinecarbaldehyde, 4-acetylpyridazine, 3-acetylpyridazine, and 3-propionylpyridazine were prepared and their cytotoxic and antiherpetic potentials were evaluated. It was found that the replacement of the 2-pyridyl-moiety in aldehyde derived compounds 20a-c by a 4-pyridazinyl group (compounds 15b-d) abolishes biological activity. However, in TSCs derived from 3-pyridazinecarbaldehyde (16b-d) the cytotoxic potency was considerably reduced (factor ~300), while the antiviral activity was largely retained. A total loss of biological activity occurred when the pyridyl group in TSC 20d, derived from 2-acetylpyridine, was replaced by the 4-pyridazinyl system (17d). By employment of the 3-pyridazinyl unit for isosteric modification, however, the cell toxicity could be reduced significantly (factor 100) without impairing the antiherpetic potential also in the series of TSCs derived from N-heteroaromatic ketones. It was observed that there is no obvious influence of the size of the cycloamino substituent on the biological activities in compounds 20a-d, 15b-d, 16b-d, 17b-d, and 18b-d. While the pyridine derived TSCs in our experiments proved clearly cytotoxic at lower concentrations than those being antivirally active, the aza-analogous compounds derived from 3-acetyl-pyridazine (18b-e) inhibited plaque formation at concentrations equal to those causing cytotoxic effects. The TSCs 16b-e derived from 3-pyridazinecarbaldehyde were found to show selective antiviral activity against HSV-1. In addition, a significant improvement of the water solubility of heteroaromatic TSCs could be achieved by the replacement of the CH-moiety in position 6 of the pyridine derivatives 20a-c by a nitrogen atom (compounds 16b-d).

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