1126425-15-7

Basic information

• Product Name: 6-Fluoro-1H-indazole-5-carbaldehyde
• Synonyms: 1H-Indazole-5-carboxaldehyde, 6-fluoro-
• CAS NO: 1126425-15-7
• Molecular Formula: C₈H₅FN₂O
• Molecular Weight: 164.137
• Mol File: 1126425-15-7.mol

Chemical Properties

• CAS DataBase Reference: 6-Fluoro-1H-indazole-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-1H-indazole-5-carbaldehyde(1126425-15-7)
• EPA Substance Registry System: 6-Fluoro-1H-indazole-5-carbaldehyde(1126425-15-7)

Safety Data

• Hazardous Substances Data: 1126425-15-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
6-Fluoro-1H-indazole-5-carbaldehyde is used as a key intermediate in the synthesis of various indazole derivatives for their potential applications in the development of new drugs. Its unique structure and properties contribute to the discovery of compounds with therapeutic benefits, particularly in the areas of anti-inflammatory, antibacterial, and anticancer treatments.
Used in Agrochemical Development:
6-Fluoro-1H-indazole-5-carbaldehyde is also utilized as a building block in the creation of new agrochemicals, where its properties can be harnessed to develop effective solutions for agricultural applications, potentially enhancing crop protection and yield.
Used in Organic Synthesis:
6-Fluoro-1H-indazole-5-carbaldehyde serves as a valuable component in organic synthesis, enabling the production of a wide range of chemical compounds with diverse applications across various industries.
Used in Fluorescent Material and Dye Synthesis:
In the field of materials science, 6-Fluoro-1H-indazole-5-carbaldehyde is used as a precursor in the synthesis of fluorescent materials and dyes. Its incorporation into these compounds can lead to the development of new products with improved properties, such as enhanced fluorescence and color characteristics, which are important in various analytical and diagnostic applications.

Upstream product

• 633335-81-6 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethan-1-one 
• 633335-80-5 N-(4-bromo-5-fluoro-2-methylphenyl)acetamide 
• 367-29-3 3-fluoro-6-methylaniline 
• 366-49-4 5’-fluoro-2’-methylacetanilide 
• 105391-70-6 5-bromo-6-fluoro-1H-indazole 
• 68-12-2 N,N-dimethyl-formamide 
• 633327-11-4 6-fluoro-1H-indazole-5-carbonitrile 

Relevant articles and documents

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics

HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have identified direct acting antivirals which have significantly improved cure rates in patients. Current

INDAZOLYL-SUBSTITUTED DIHYDROISOXA-ZOLOPYRIDINES AND METHODS OF USE THEREOF

This invention relates to novel 4-(indazol-5-yl)-4,7-dihydroisoxazolo[5,4-b]pyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseas

FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for

BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF

This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated

ANNELLATED 4- (INDAZOLYL) -1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF

This invention relates to novel annellated 4-(indazolyl)-l,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-

2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS

The present invention relates to 2,3-Substituted Azaindole Derivatives, compositions comprising at least one 2,3-Substituted Azaindole Derivatives, and methods of using the 2,3-Substituted Azaindole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE

The invention relates to compounds of formula (I) and salts thereof, formula (I) wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharamaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).

TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient