- The process development of a novel aldose reductase inhibitor, FK366. Part 1. Improvement of discovery process and new syntheses of 1-substituted quinazolinediones
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This contribution describes part 1 of process development of a novel aldose reductase inhibitor FK366 (1). The original process applied on a laboratory scale was improved from the safety viewpoint to manufacture materials on 500-L scale suitable for toxic
- Goto, Shunsuke,Tsuboi, Hiroyuki,Kanoda, Masami,Mukai, Koji,Kagara, Kooji
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- USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
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The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
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- PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVE OR SALT THEREOF
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This invention provides a novel industrial process for preparation of a quinazoline derivative (I) represented by the general formula: in which R1 is hydrogen or halogen,R2 is protected carboxy,R3 is ar(lower)alkyl which m
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- Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
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A process for preparing a 3-dihalobenzyl-2,4-quinazolinedione derivative represented by the formula (V): (wherein X1, X2, X3are independently a halogen atom, and A is an alkylene group), which comprises: reacting a dihalob
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- Quinazoline derivatives, compositions thereof and their use in treating diabetic complications
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The invention relates to compounds of the formula: STR1 in which R1 and R2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R3 is dihalophenyl, naphthyl(lower)alkyl, phenyl(lower)alkyl substituted by one or two substituent(s) selected from the group consisting of halogen, lower alkoxy, halo(lower)alkyl and lower alkyl, or thienyl(lower)alkyl, R4 is carboxy or protected carboxy, Y is carbonyl, thiocarbonyl or sulfonyl and Z is lower alkylene, and pharmaceutically acceptable salts thereof, useful in the treatment of diabetic complications.
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