112733-28-5

Upstream product

• 112733-45-6 ethyl 2-(7-chloro-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-1-yl)acetate 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 13165-35-0 7-chloroquinazoline-2,4-dione 
• 214288-97-8 4-chloro-2-ureido-benzoic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 105-36-2 ethyl bromoacetate 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 112733-11-6 sodium 2-[3-(4-bromo-2-fluorobenzyl)-7-chloro-1,2,3,4-tetrahydro-2,4-dioxoquinazolin-1-yl]acetate 
• 112733-06-9 zenarestat 

Relevant academic research and scientific papers

Efficient preparation of 3-substituted quinazolinediones directly from anthranilic acids and isocyanates

An efficient and practical synthesis of 3-substituted quinazolinediones is described. The protocol uses readily available isocyanates and anthranilic acids as precursors in a one-pot operation and has been demonstrated on >50 g scale. Isolation of the pro

The process development of a novel aldose reductase inhibitor, FK366. Part 1. Improvement of discovery process and new syntheses of 1-substituted quinazolinediones

This contribution describes part 1 of process development of a novel aldose reductase inhibitor FK366 (1). The original process applied on a laboratory scale was improved from the safety viewpoint to manufacture materials on 500-L scale suitable for toxic

PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVE OR SALT THEREOF

This invention provides a novel industrial process for preparation of a quinazoline derivative (I) represented by the general formula: in which R1 is hydrogen or halogen,R2 is protected carboxy,R3 is ar(lower)alkyl which m

Quinazoline derivatives, compositions thereof and their use in treating diabetic complications

The invention relates to compounds of the formula: STR1 in which R1 and R2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R3 is dihalophenyl, naphthyl(lower)alkyl, phenyl(lower)alkyl substituted by one or two substituent(s) selected from the group consisting of halogen, lower alkoxy, halo(lower)alkyl and lower alkyl, or thienyl(lower)alkyl, R4 is carboxy or protected carboxy, Y is carbonyl, thiocarbonyl or sulfonyl and Z is lower alkylene, and pharmaceutically acceptable salts thereof, useful in the treatment of diabetic complications.