cas 112741-49-8, tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

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112741-49-8

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Chiral morphine quinoline compound preparation method and chiral amino acid preparation method of compound
The invention provides chiral morpholine compounds. The structural general formula of the chiral morpholine compounds is as shown in the description. The invention further comprises a preparation method of the chiral morpholine compounds. The chiral morpholine compounds are prepared by using benzoin as a starting material, performing reductive amination, and performing chemical resolution on enantiomers and acid-catalyzed ester condensation reaction. The invention further provides amino acid compounds prepared from the chiral morpholine compounds, and a preparation method and application of the amino acid compounds.
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(2017/12/13)

Monosubstituted alkenyl amino acids for peptide "stapling"
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
Yeo, David J.,Warriner, Stuart L.,Wilson, Andrew J.
supporting information
p. 9131 - 9133
(2013/09/24)

An improved synthesis of optically pure 4-Boc-5,6-diphenylmorpholin-2-one and 4-Cbz-5,6-diphenylmorpholin-2-one
A convenient synthesis of optically pure 4-Boc-5,6-diphenylmorpholin-2-one and 4-Cbz-5,6-diphenylmorpholin-2-one by reaction of (+)- or (-)-2-amino-1,2-diphenylethanol with ethyl bromoacetate, followed by N-protection, and p-TsOH-mediated ring-closure is
Dastlik, Kim A.,Sundermeier, Uta,Johns, Deidre M.,Chen, Yuyin,Williams, Robert M.
p. 693 - 696
(2007/10/03)

Asymmetric synthesis of N-tert-butoxycarbonyl α- Amino acids. synthesis of (5S,6R)-4-tert-butoxycarbonyl-5,6-diphenylmorpholin-2-ONE [(4-Morpholinecarboxylic acid, 6-oxo-2,3-diphenyl-, 1,1-dimethylethyl ester, (2S,3R)-)]
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Williams, Robert M.,Sinclair, Peter J.,DeMong, Duane E.,Chen, Daimo,Zhai, Dongguan
p. 18 - 30
(2017/09/19)

Practical Asymmetric Syntheses of α-Amino Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine Templates
The optically active D- and L-erythro-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) and D- and L-erythro-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) can be efficiently brominated to serve as electrophilic glycine templates for the asymmetric synthesis of amino acids.It was found that coupling to these templates can proceed with either net retention or net inversion of stereochemistry.The final deblocking to the amino acids is accomplished with either dissolving-metal reduction or catalytic hydrogenolysis.The syntheses of β-ethyl aspartic acid, norvaline, allylglycine, alanine, norleucine, homophenylalanine, p-methoxyhomophenylalanine, cyclopentylglycine, and cyclopentenylglycine and a formal synthesis of clavalanine are described.In addition, the direct asymmetric syntheses of N-t-BOC-allylglycine and N-t-BOC-cyclopentenylglycine are described.
Williams, Robert M.,Sinclair, Peter J.,Zhai, Dongguan,Chen, Daimo
p. 1547 - 1557
(2007/10/02)

Chemical Properties

Appearance/Colour :white powder
Melting Point: 206 °C (dec.)(lit.)
Boiling Point: 509.6 °C at 760 mmHg
Flash Point:262 °C
Density: 1.175 g/cm³
Solubility:Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly), DMSO (Slightly, So
Storage Temp.:2-8°C
Vapor Pressure: 1.67E-10mmHg at 25°C
Refractive Index: 1.561
PKA: -3.28±0.60(Predicted)
PSA: 55.84000
LogP: 4.20080

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112741-49-8

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Chemical Properties

Appearance/Colour :white powder

Melting Point: 206 °C (dec.)(lit.)

Boiling Point: 509.6 °C at 760 mmHg

Flash Point:262 °C

Density: 1.175 g/cm³

Solubility:Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly), DMSO (Slightly, So

Storage Temp.:2-8°C

Vapor Pressure: 1.67E-10mmHg at 25°C

Refractive Index: 1.561

PKA: -3.28±0.60(Predicted)

PSA: 55.84000

LogP: 4.20080

Global suppliers and manufacturers of 112741-49-8total 65 suppliers on LookChem

Article Database

112741-49-8

Articles about 112741-49-8Total 5 be found

More Articles about upstream products of 112741-49-8

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Chemical Properties

Appearance/Colour :white powder

Melting Point: 206 °C (dec.)(lit.)

Boiling Point: 509.6 °C at 760 mmHg

Flash Point:262 °C

Density: 1.175 g/cm3

Solubility:Acetone (Slightly, Heated, Sonicated), Chloroform (Slightly), DMSO (Slightly, So

Storage Temp.:2-8°C

Vapor Pressure: 1.67E-10mmHg at 25°C

Refractive Index: 1.561

PKA: -3.28±0.60(Predicted)

PSA: 55.84000

LogP: 4.20080

Global suppliers and manufacturers of 112741-49-8total 65 suppliers on LookChem

Density: 1.175 g/cm³