- Chiral morphine quinoline compound preparation method and chiral amino acid preparation method of compound
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The invention provides chiral morpholine compounds. The structural general formula of the chiral morpholine compounds is as shown in the description. The invention further comprises a preparation method of the chiral morpholine compounds. The chiral morpholine compounds are prepared by using benzoin as a starting material, performing reductive amination, and performing chemical resolution on enantiomers and acid-catalyzed ester condensation reaction. The invention further provides amino acid compounds prepared from the chiral morpholine compounds, and a preparation method and application of the amino acid compounds.
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Paragraph 0105; 0107; 0111; 0115
(2017/12/13)
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- Monosubstituted alkenyl amino acids for peptide "stapling"
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Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
- Yeo, David J.,Warriner, Stuart L.,Wilson, Andrew J.
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supporting information
p. 9131 - 9133
(2013/09/24)
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- An improved synthesis of optically pure 4-Boc-5,6-diphenylmorpholin-2-one and 4-Cbz-5,6-diphenylmorpholin-2-one
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A convenient synthesis of optically pure 4-Boc-5,6-diphenylmorpholin-2-one and 4-Cbz-5,6-diphenylmorpholin-2-one by reaction of (+)- or (-)-2-amino-1,2-diphenylethanol with ethyl bromoacetate, followed by N-protection, and p-TsOH-mediated ring-closure is
- Dastlik, Kim A.,Sundermeier, Uta,Johns, Deidre M.,Chen, Yuyin,Williams, Robert M.
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p. 693 - 696
(2007/10/03)
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- Optically active carboalkylated amino alcohols and their utilization in optical resolution
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A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alc
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- Practical Asymmetric Syntheses of α-Amino Acids through Carbon-Carbon Bond Constructions on Electrophilic Glycine Templates
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The optically active D- and L-erythro-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) and D- and L-erythro-4-(tert-butoxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-ones (3) can be efficiently brominated to serve as electrophilic glycine templates for the asymmetric synthesis of amino acids.It was found that coupling to these templates can proceed with either net retention or net inversion of stereochemistry.The final deblocking to the amino acids is accomplished with either dissolving-metal reduction or catalytic hydrogenolysis.The syntheses of β-ethyl aspartic acid, norvaline, allylglycine, alanine, norleucine, homophenylalanine, p-methoxyhomophenylalanine, cyclopentylglycine, and cyclopentenylglycine and a formal synthesis of clavalanine are described.In addition, the direct asymmetric syntheses of N-t-BOC-allylglycine and N-t-BOC-cyclopentenylglycine are described.
- Williams, Robert M.,Sinclair, Peter J.,Zhai, Dongguan,Chen, Daimo
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p. 1547 - 1557
(2007/10/02)
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- Novel Chiral Stationary Phases for the Resolution of the Enantiomers of Amino Acids by Ligand Exchange Chromatography
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Novel chemically bonded chiral stationary phases (CSP's) derived from (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol and from (1S,2S)-2-carboxymethylamino-1,2-diphenylethanol were prepared.The ligand exchange chromatography on these CSP's was found to b
- Yuki, Yoichi,Saigo, Kazuhiko,Tachibana, Kouzou,Hasegawa, Masaki
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p. 1347 - 1350
(2007/10/02)
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