A ONE-POT TRANSFORMATION OF KETONES INTO N-(METH)ACRYLOYL-2-AMINO ACIDS
A synthetic sequence for the preparation of N-(meth)acryloyl-2-amino acids is outlined which involves transformation of a ketone successively into an aminonitrile and a (meth)acrylamidonitrile, followed by selective hydrolysis of the nitrile function.All reactions are performed in aqueous media, in one reaction vessel, and in a stepwise manner without isolation of any intermadiate products.
Heilmann, Steven M.,Jensen, Karen M.,Krepski, Larry R.,Moren, Dean M.,Rasmussen, Jerald K.
p. 843 - 862
(2007/10/02)
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