- Anticancer screening and structure activity relationship study of some semicarbazides and 1,2,4-Triazolin-5-ones
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In this paper some semicarbazide and 1,2,4-triazolin-5-one derivatives are evaluated in vitro for their anticancer activity towards human tumour cell line: ovary (TOV 112D), lung (A 549), breast (T47D) and uterus (Hela). Compounds 2-4 have been found to s
- Pitucha, Monika,Rzymowska, Jolanta
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scheme or table
p. 568 - 572
(2012/09/08)
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- Antioxidant evaluation of some semicarbazide, 1,2,4-triazolone and pyrazolone derivatives
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1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone. The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).
- Pitucha, Monika,Nowak, Renata
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experimental part
p. 1004 - 1008
(2012/07/03)
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- Synthesis and antinociceptive activity of 4,4'-bis(1-substituted- semicarbazidyl)diphenylmethane and 4,4-bis(5-substituted-2,4-dihydro-3-oxo-3H-1, 2,4- triazol-4-yl)diphenylmethane derivatives
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In the reaction of 4,4'-diphenylmethane diiso-cyanate with carboxylic acid hydrazides, 4,4'-bis(1- substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihy- dro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed. Springer-Verlag 2010.
- Pitucha, Monika,Chodkowska, Anna,MacIejewski, Mariusz,Jagiello-Wojtowicz, Ewa,Pachuta-Stec, Anna
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body text
p. 199 - 203
(2010/08/05)
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- Synthesis, experimental and theoretical investigations of some new 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives
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The 4,4′-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane derivatives 3 were synthesized in the cyclization reaction of semicarbazide derivatives 2 in alkaline solution. The synthesized compounds were characterized by elemental an
- Pitucha, Monika,Borowski, Piotr,Karczmarzyk, Zbigniew,Fruziński, Andrzej
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experimental part
p. 170 - 177
(2009/06/20)
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