1130206-88-0

Basic information

• Product Name: 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane
• Synonyms: 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane
• CAS NO: 1130206-88-0
• Molecular Weight: 514.586
• Mol File: 1130206-88-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane(1130206-88-0)
• EPA Substance Registry System: 4,4'-bis(3-benzyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)diphenylmethane(1130206-88-0)

Safety Data

• Hazardous Substances Data: 1130206-88-0(Hazardous Substances Data)

Upstream product

• 937-39-3 2-phenylacetylhydrazine 
• 101-68-8 di(4-isocyanatophenyl)methane 
• 1130206-84-6 4,4'-bis(1-phenylacetyl-semicarbazide)diphenylmethane 

Relevant articles and documents

Anticancer screening and structure activity relationship study of some semicarbazides and 1,2,4-Triazolin-5-ones

In this paper some semicarbazide and 1,2,4-triazolin-5-one derivatives are evaluated in vitro for their anticancer activity towards human tumour cell line: ovary (TOV 112D), lung (A 549), breast (T47D) and uterus (Hela). Compounds 2-4 have been found to s

Synthesis and antinociceptive activity of 4,4'-bis(1-substituted- semicarbazidyl)diphenylmethane and 4,4-bis(5-substituted-2,4-dihydro-3-oxo-3H-1, 2,4- triazol-4-yl)diphenylmethane derivatives

In the reaction of 4,4'-diphenylmethane diiso-cyanate with carboxylic acid hydrazides, 4,4'-bis(1- substituted-semicarbazidyl)diphenylmethane derivatives were obtained. Depending on their chemical nature, cyclization of these compounds in alkaline medium led to the formation of two groups of compounds: bis(2,4-dihy- dro-3H-1,2,4-triazol-3-one) derivatives or carboxylic acids. The pharmacological effects of the selected compounds on the central nervous system in mice were investigated. Strong antinociceptive properties of some derivatives, at a wide range of doses, were observed. Springer-Verlag 2010.