113450-48-9

Basic information

• Product Name: 4-METHYL-N-(4-MORPHOLINOPHENYL)BENZENESULFONAMIDE
• Synonyms: 4-METHYL-N-(4-MORPHOLINOPHENYL)BENZENESULFONAMIDE;4-methyl-N-[4-(morpholin-4-yl)phenyl]benzene-1-sulfonamide
• CAS NO: 113450-48-9
• Molecular Formula: C17H20N2O3S
• Molecular Weight: 332.42
• Mol File: 113450-48-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHYL-N-(4-MORPHOLINOPHENYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-N-(4-MORPHOLINOPHENYL)BENZENESULFONAMIDE(113450-48-9)
• EPA Substance Registry System: 4-METHYL-N-(4-MORPHOLINOPHENYL)BENZENESULFONAMIDE(113450-48-9)

Safety Data

• Hazardous Substances Data: 113450-48-9(Hazardous Substances Data)

Upstream product

• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

DNA interaction and anticancer properties of new peripheral phthalocyanines carrying tosylated 4-morpholinoaniline units

In this paper, tosylated 4-morpholinoaniline units fused peripherally tetra-substituted free-base (5), copper(II) (6), zinc(II) (7), cobalt(II) (8) and magnesium(II) (9) phthalocyanines (Scheme 1) were reported and these new phthalocyanine conjugates were characterized through Fourier Transform–Infrared (FT–IR) with ATR sampling accessory, Mass Spectra Analysis [Matrix Assisted Laser Desorption/Ionization–Time of Flight–Mass Spectral (MALDI–TOF–MS)] and Ultraviolet–visible (UV–vis) (for all new phthalocyanines), elemental analysis, as well as 1H and 13C NMR spectroscopic techniques [for the compounds (2), (4), (5), (7) and (9)]. The potential utilization of the new peripheral phthalocyanine compounds (7–9) as the new pharmaceutical agents in PDT applications (in oncology and molecular biology) were determined in aspects of pBR322 plasmid DNA cleavage on agarose gel electrophoresis. The results showed that compound (7) cleaved pBR322 plasmid DNA with irradiation. Compound (7) displayed hypochromism without any shift on the addition of increasing concentrations of ct-DNA and Kb of compound (7) was calculated as 2.45 ± (0.20) × 104 M?1. In photochemical studies, the ΦΔ value of compound (7) was determined as 0.11. The cytotoxic/phototoxic properties of compound (7) which had the best photocleavage effects among tested compounds were investigated using MTT assay toward human colorectal (HCT-116) and cervical (HeLa) cancer cells. The cell viabilities of compound (7) were found to be 73 ± 1.6% (HCT-116) and 65 ± 5.5% (HeLa) at 100 μM with irradiation.

Syntheses, structural characterization, DNA-cleavage and antioxidant features of the new tetra-substituted organo-soluble non-peripherally CoII, CuII, ZnII and MgII phthalocyanines

This paper encompasses the synthesis, structural characterization, and evaluation of supercoiled pBR322 plasmid DNA-cleavage and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging properties of newly synthesized tetra-substituted CoII (5),