2524-67-6

Basic information

• Product Name: 4-Morpholinoaniline
• Synonyms: p-Morpholinoaniline, 98+%;4-(4-Morpholinyl)aniline;4-(4-Morpholinyl)aniline, 98+%;4-Morpholinoaniline,97.3%;4-morpholinobenzenamine;N-(4-Aminophenyl)morpholine ,97%;4-Morpholine Aniline;4-(Morpholin-4-yl)anilines
• CAS NO: 2524-67-6
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• EINECS: 219-760-1
• Product Categories: Aromatic Morpholines;pharmacetical;Building Blocks;Heterocyclic Building Blocks;Morpholines
• Mol File: 2524-67-6.mol
• Article Data: 94

Chemical Properties

• Melting Point: 132-135 °C(lit.)
• Boiling Point: 310.47°C (rough estimate)
• Flash Point: 176.4 °C
• Appearance: Purple to brown/Crystalline Powder
• Density: 1.0777 (rough estimate)
• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Soluble in chloroform, ethyl acetate.
• PKA: 6.72±0.40(Predicted)
• BRN: 150957
• CAS DataBase Reference: 4-Morpholinoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinoaniline(2524-67-6)
• EPA Substance Registry System: 4-Morpholinoaniline(2524-67-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36/37/39-22
• RIDADR: UN2811
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 6.1
• Hazardous Substances Data: 2524-67-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2524-67-6 differently. You can refer to the following data:
1. 4-Morpholinoaniline is a morpholine derivative used in the preparation of central nervous system (CNS) active agents. 4-Morpholinoaniline is also one of the primary aromatic amines used in the colour developing process in photographs.
2. 4-(4-Morpholinyl)aniline is used in the preparation of central nervous system (CNS) active agents, also used in the color developing process in photographs.

InChI:InChI=1/C10H14N2O/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8,11H2

Upstream product

• 10389-51-2 1-morpholino-4-nitrobenzene 
• 110-91-8 morpholine 
• 106-40-1 4-bromo-aniline 
• 5382-54-7 4-(4-nitroso-phenyl)-morpholine 
• 39910-98-0 4-morpholinoacetophenone 
• 115833-91-5 1-(4-(4-morpholinylphenyl))ethan-1-ol 
• 371-40-4 4-fluoroaniline 
• 106-39-8 bromochlorobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 30483-75-1 4-bromophenyl-morpholine 
• 586-78-7 para-nitrophenyl bromide 
• 106-47-8 4-chloro-aniline 
• 70291-67-7 N-(4-chlorophenyl)morpholine 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 4433-80-1 acetoacetic acid-(4-morpholino-anilide) 
• 7253-93-2 2-[(4-Morpholino-phenylimino)-methyl]-phenol 
• 301157-20-0 N-(4-morpholinophenylcarbamothioyl)benzamide 
• 130956-92-2 2-methyl-4-(4-morpholino-phenylimino)-cyclohexa-2,5-dienone 
• 95003-50-2 3-hydroxy-[2]naphthoic acid-(4-morpholino-anilide) 
• 103913-29-7 N-(4-morpholin-4-yl-phenyl)-acetamide 
• 68944-95-6 4-morpholin-4-yl-N-(2-p-tolyl-indol-3-ylmethylene)-aniline 
• 27311-28-0 2-hydroxy-N-(4-morpholin-4-yl-phenyl)-2-phenyl-acetamide 
• 104686-86-4 (7-methyl-1⁽³⁾H-imidazo[4,5-f]quinolin-9-yl)-(4-morpholin-4-yl-phenyl)-amine 
• 286958-45-0 3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide 
• 663948-77-4 [1-(4-morpholin-4-yl-phenylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex

The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.

Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents: A Direct Approach to Anilines?

Amines are among the most fundamental motifs in chemical synthesis, and the introduction of amine building blocks via selective C—C bond cleavage allows the construction of nitrogen compounds from simple hydrocarbons through direct skeleton modification. Herein, we report a novel method for the preparation of anilines from alkylarenes via Schmidt-type rearrangement using redox-active amination reagents, which are easily prepared from hydroxylamine. Primary amines and secondary amines were prepared from corresponding alkylarenes or benzyl alcohols under mild conditions. Good compatibility and valuable applications of the transformation were also displayed.

2, 6, 8 - Polysubstituted imidazo [1, 2 - a] pyrazine and synthesis method and application thereof

The invention discloses I, 2 and 6 polysubstituted imidazo [8 - 1] pyrazine of formula (2 - a) or a pharmaceutically acceptable salt thereof. The invention also discloses application of the 2, 6 and 8 - polysubstituted imidazo [1, 2 - a] pyrazine or pharmaceutically acceptable salts thereof as TYK2 inhibitors in preparation of drugs for preventing and treating tumor or inflammation diseases. The invention also provides a synthetic method of the 2, 6, 8 - polysubstituted imidazo [1, 2 - a] pyrazine or a pharmaceutically acceptable salt thereof.