113486-84-3

Basic information

• Product Name: methyl 4-(6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenyl ether
• Synonyms: methyl 4-(6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenyl ether
• CAS NO: 113486-84-3
• Molecular Formula: C₁₆H₁₂N₄OS
• Molecular Weight: 308.35768
• Mol File: 113486-84-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 4-(6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenyl ether(113486-84-3)
• EPA Substance Registry System: methyl 4-(6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenyl ether(113486-84-3)

Safety Data

• Hazardous Substances Data: 113486-84-3(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 36209-49-1 4-amino-5-(4-methoxyphenyl)-2,3-dihydro-4H-1,2,4-triazole-3-thione 

Relevant articles and documents

3. 6 - Disubstituted [1, 2, 4] triazolo [3, 4 - b] [1, 3, 4] thiadiazole compound and use thereof

The invention discloses 3,6-disubstituted[1,2,4]triazolyl[3,4-b][1,3,4]thiadiazole compounds represented by general formula (I), and pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof. The compounds can be used as a transpeptidase SrtA inhibitor of Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis, Streptococcus pneumoniae and other Gram-positive bacteria, and can be used to prepare drugs for treating pathogen infection diseases with the transpeptidase SrtA of the Gram-positive bacteria, such as Staphylococcus aureus, Bacillus pyogenes, Bacillus anthracis and Streptococcus pneumoniae as target. The compounds avoid selection pressure induced drug resistance of pathogens to a certain degree, and mitigate threat of continuous drug-resistant pathogens to the health of human.

Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives

The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.