113732-62-0

Basic information

• Product Name: 2-bromo-1-(2,5-dimethyl-4-oxazolyl)
• Synonyms: 2-bromo-1-(2,5-dimethyl-4-oxazolyl);Ethanone, 2-bromo-1-(2,5-dimethyl-4-oxazolyl)- (9CI);2-Bromo-1-(2,5-dimethyl-oxazol-4-yl)-ethanone;2-BROMO-1-(2,5-DIMETHYL-4-OXAZOLYL) ETHANONE;Ethanone, 2-bromo-1-(2,5-dimethyl-4-oxazolyl)-;2-bromo-1-(2,5-dimethyl-1,3-oxazol-4-yl)ethanone
• CAS NO: 113732-62-0
• Molecular Formula: C₇H₈BrNO₂
• Molecular Weight: 218.04792
• Product Categories: ACETYLHALIDE
• Mol File: 113732-62-0.mol

Chemical Properties

• Melting Point: 175-176 °C
• Boiling Point: 257.856 °C at 760 mmHg
• Flash Point: 109.748 °C
• Appearance: /
• Density: 1.528 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.50±0.10(Predicted)
• CAS DataBase Reference: 2-bromo-1-(2,5-dimethyl-4-oxazolyl)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(2,5-dimethyl-4-oxazolyl)(113732-62-0)
• EPA Substance Registry System: 2-bromo-1-(2,5-dimethyl-4-oxazolyl)(113732-62-0)

Safety Data

• Hazardous Substances Data: 113732-62-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-bromo-1-(2,5-dimethyl-4-oxazolyl) is used as a key intermediate in the synthesis of various pharmaceuticals for its high reactivity and versatility in chemical reactions. It aids in the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-bromo-1-(2,5-dimethyl-4-oxazolyl) is utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2-bromo-1-(2,5-dimethyl-4-oxazolyl) is employed as a building block in organic synthesis, enabling the creation of more complex molecules with diverse applications in various fields.
Used as an Anti-cancer Agent:
Research has demonstrated the potential of 2-bromo-1-(2,5-dimethyl-4-oxazolyl) as an anti-cancer agent, making it a promising candidate for further investigation and development in oncology.
Used as an Anti-inflammatory Agent:
2-bromo-1-(2,5-dimethyl-4-oxazolyl) has also shown potential as an anti-inflammatory agent, indicating its possible use in the treatment of various inflammatory conditions.

InChI:InChI=1/C7H8BrNO2/c1-4-7(6(10)3-8)9-5(2)11-4/h3H2,1-2H3

Upstream product

• 23000-12-6 1-(2,5-dimethyloxazol-4-yl)ethanone 
• 5440-23-3 3-(acetylamino)-2,4-pentanedione 

Downstream Products

• 103793-55-1 4-[2-(2,5-Dimethyl-4-oxazolyl)-2-hydroxyethoxy]aniline 
• 103789-11-3 4-[2-(2,5-Dimethyl-4-oxazolyl)-2-hydroxyethoxy]acetanilide 
• 103788-33-6 5-{4-[2-(2,5-dimethyl-4-oxazolyl)-2-oxoethoxy]benzyl}-2,4-thiazolidinedione 
• 103788-11-0 5-{4-[2-(2,5-dimethyl-4-oxazolyl)-2-hydroxyethoxy]benzyl}-2,4-thiazolidinedione 
• 103789-12-4 5-{4-[2-(2,5-Dimethyl-oxazol-4-yl)-2-hydroxy-ethoxy]-benzyl}-2-imino-thiazolidin-4-one 

Relevant articles and documents

Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents

In the course of further chemical modification of the novel antidiabetic pioglitazone (AD-4833, U-72, 107), a series of 5-[4-(2- or 4- azolylalkoxy)benzyl- or -benzylidene]-2,4-thiazolidinediones was prepared and evaluated for hypoglycemic and hypolipidemic activities in insulin-resistant, genetically obese, and diabetic KKA(y) mice. Replacement of the 2-pyridyl moiety of pioglitazone by a 2- or 4-oxazolyl or a 2- or 4-thiazolyl moiety greatly enhanced in vivo potency. The corresponding 5-benzylidene-type compounds, in which a methine was used as a linker between the benzene ring and the thiazolidinedione ring, also had potent biological activity. Among the compounds synthesized, 5-[4-[2-(5-methyl-2-phenyl-4- oxazolyl)ethoxy]benzyl]-2,4-thiazolidinedione (18) exhibited the most potent activity, more than 100 times that of pioglitazone. The synthesis and structure-activity relationships for this novel series of derivatives are detailed.

Substituted thiazoles and oxazoles and 2-hydroxy-morpholines

Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.