113772-16-0

Basic information

• Product Name: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE
• Synonyms: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE;2,5-Dihydro-3-thiophenecarboxaldehyde
• CAS NO: 113772-16-0
• Molecular Formula: C₅H₆OS
• Molecular Weight: 114.17
• Product Categories: Aldehydes;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 113772-16-0.mol

Chemical Properties

• Boiling Point: 226.5 °C at 760 mmHg
• Flash Point: 114.4 °C
• Appearance: /
• Density: 1.326 g/cm³
• Vapor Pressure: 0.0818mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(113772-16-0)
• EPA Substance Registry System: 2,5-DIHYDROTHIOPHENE-3-CARBALDEHYDE(113772-16-0)

Safety Data

• Hazardous Substances Data: 113772-16-0(Hazardous Substances Data)

Usage

Uses

Used in Fragrance Industry:
2,5-Dihydrothiophene-3-carbaldehyde is used as a fragrance ingredient for its distinctive scent, contributing to the formulation of perfumes and personal care products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2,5-Dihydrothiophene-3-carbaldehyde serves as a key building block in the synthesis of various medicinal compounds, leveraging its reactivity in organic chemistry for the development of new drugs.
Used in Agrochemical Industry:
2,5-Dihydrothiophene-3-carbaldehyde is utilized in the production of agrochemicals, where its chemical properties are harnessed to create effective products for agricultural applications.
Safety Note:
It is crucial to handle 2,5-Dihydrothiophene-3-carbaldehyde with care due to its potential harmful effects if inhaled, ingested, or comes into contact with the skin, emphasizing the need for proper safety measures during its use in various industries.

InChI:InChI=1/C5H6OS/c6-3-5-1-2-7-4-5/h1,3H,2,4H2

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 107-02-8 acrolein 
• 4594-63-2 3-hydroxy-tetrahydro-thiophene-3-carbonitrile 

Downstream Products

• 498-62-4 3-thiophene carboxaldehyde 

Relevant articles and documents

A short, practical synthesis of 3-thiophenecarboxaldehyde

The compound 3-thiophenecarboxaldehyde (2) was prepared in multi-kilogram quantities by a novel two-step process involving the condensation of acrolein with 1,4-dithiane-2,5-diol, followed by sulfuryl chloride-mediated oxidation.

Preparation method of 3-thiophenecarboxaldehyde

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 3-thiophenecarboxaldehyde. The preparation method of 3-thiophenecarboxaldehyde comprises thefollowing steps: performing reaction on 1,1,3,3-tetramethoxypropane under the acidic condition, performing mixed reaction on the reaction product and 1,4-dithio-2,5-diol under the alkaline conditionand performing aftertreatment to obtain the 3-thiophenecarboxaldehyde. By the preparation method of 3-thiophenecarboxaldehyde, the 3-thiophenecarboxaldehyde product with the purity exceeding 98 percent can be prepared only through simple mixing and stirring reaction, reaction does not need ultralow temperature and dangerous reagents in the preparation process, and the production safety coefficientis increased. Furthermore, the preparation method provided by the invention is simple in operation, the raw materials are easily available, operation cost and raw material cost are reduced, and the preparation method is suitable for industrialized production of 3-thiophenecarboxaldehyde.

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.