- RIFAMYCIN ANALOGS AND ANTIBODY-DRUG CONJUGATES THEREOF
-
The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureus infections). The disclosure further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific for infectious disease-related targets such as membrane glycoprotein receptor (MSR1), wall teichoic acids (WTA) or Protein A, and methods of use thereof to inhibit bacterial growth and treat bacterial infections.
- -
-
Paragraph 000850-000851
(2020/07/14)
-
- SOMATOSTATIN MODULATORS AND USES THEREOF
-
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or diso
- -
-
Paragraph 0386-0387
(2020/03/28)
-
- NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
-
The present invention discloses compounds according to Formula (I), wherein R1, R3, R4, R5, L1, and Cy are as defined herein. The present invention also provides compounds, methods for the production of said compounds of the invention, pharmaceutical compositions comprising the same and their use in allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 and/or interferons. The present invention also methods for the prevention and/or treatment of the aforementioned diseases by administering a compound of the invention.
- -
-
Paragraph 0728
(2017/02/09)
-
- POLO-LIKE KINASE INHIBITORS
-
Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates use
- -
-
Page/Page column 364-365
(2009/05/29)
-
- Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors
-
A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
- Yin, Yan,Lin, Li,Ruiz, Claudia,Cameron, Michael D.,Pocas, Jennifer,Grant, Wayne,Schroeter, Thomas,Chen, Weimin,Duckett, Derek,Schuerer, Stephan,LoGrasso, Philip,Feng, Yangbo
-
scheme or table
p. 6686 - 6690
(2010/06/14)
-