- Microwave-assisted solvent-free synthesis of highly functionalized pyrimidine derivatives
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We here described an efficient method for the synthesis of a series of highly functionalized pyrimidines via the addition and condensation reaction of ketene dithioacetals with guanidine carbonate or amidine hydrochlorides by microwave irradiation under s
- Yan, Shengjiao,Niu, Yanfei,Chen, Xuebing,Liu, Yongjiang,Lin, Jun
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p. 877 - 882
(2012/10/30)
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- Nucleophilic Substitutions and Eliminations of Amino Functions via Pyrimidinium Salts
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Reaction of 2,4-diphenyl-1,3-thiazine-6-thione (1) with primary amines leads under ring transformation to 1-organyl-pyrimidine-6-thiones 3, which are alkylated to 1-organyl-6-methylthiopyrimidinium salts 5.The latter allow a transfer of the 1-organyl group to nucleophilic agents by departure of 2,4-diphenyl-6-methylthio-pyrimidine (8).In special cases an elimination reaction is successful.Preparative advantages and limitations are demonstrated and discussed. - Keywords: 1,3-Thiazine-6-thione; Pyrimidine-6-thiones; Pyrimidinium salts; Nucleophilic substitution; Elimination reaction
- Spitzner, Roland,Lesinski, Markus,Richter, Monika,Schroth, Werner
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p. 485 - 502
(2007/10/02)
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