114012-43-0

Basic information

• Product Name: (3-phenyloxetan-3-yl)methanol
• Synonyms: (3-phenyloxetan-3-yl)methanol;3-Hydroxymethyl-3-phenyloxetane;3-Phenyl-3-oxetaneMethanol
• CAS NO: 114012-43-0
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 114012-43-0.mol

Chemical Properties

• Boiling Point: 286℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.146
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Sparingly)
• PKA: 14.58±0.10(Predicted)
• CAS DataBase Reference: (3-phenyloxetan-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-phenyloxetan-3-yl)methanol(114012-43-0)
• EPA Substance Registry System: (3-phenyloxetan-3-yl)methanol(114012-43-0)

Safety Data

• Hazardous Substances Data: 114012-43-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(3-Phenyloxetan-3-yl)methanol is used as a synthetic intermediate for the production of herbicides and pesticides. Its chemical structure allows for further functionalization and incorporation into more complex molecules, making it a valuable building block in the agrochemical industry.
Used in Pharmaceutical Industry:
(3-Phenyloxetan-3-yl)methanol can also be utilized as a starting material or intermediate in the development of pharmaceutical compounds. Its unique structure may contribute to the creation of novel drugs with specific therapeutic properties.
Used in Research and Development:
Due to its potential applications in various fields, (3-phenyloxetan-3-yl)methanol is often employed in research and development settings. Scientists and chemists use this compound to explore new reaction pathways, develop innovative synthetic methods, and create new molecules with potential applications in various industries.

Upstream product

• 4704-99-8 α,α,α-tris(hydroxymethyl)toluene 
• 37434-59-6 dimethyl 2-phenylmalonate 
• 1620017-10-8 tert-butyldiphenyl[(3-phenyloxetan-3-yl)methoxy]silane 
• 1620017-09-5 2-[(tert-butyldiphenylsilyloxy)methyl]-2-phenylpropane-1,3-diol 
• 1620017-08-4 dimethyl 2-[(tert-butyldiphenylsilyloxy)methyl]-2-phenylmalonate 
• 124604-01-9 dimethyl 2-(hydroxymethyl)-2-phenylmalonate 

Downstream Products

• 428512-49-6 3-phenyloxetan-3-ylmethyl benzoate 
• 497239-45-9 (3-phenyloxetan-3-yl)methanamine 
• 85946-91-4 1,4-diphenyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 497239-46-0 N-(3-phenyloxetan-3-ylmethyl)benzamide 
• 215719-46-3 2,3-benzo-7-phenyl-9,10-dioxa-5-azatricyclo[5.2.2.0^1,5]undec-2-en-4-one 
• 215719-41-8 2-(3-phenyloxetan-3-ylmethyl)isoindole-1,3-dione 
• 215719-44-1 (3-phenyl-oxetan-3-yl)methyl p-toluenesulfonate 

Relevant articles and documents

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

Unusual cyclodimerization of small cyclic ethers via neighboring carbonyl-group participation and cation transfer

Oxetanes having both a carbonyl functional group and a phenyl group at the 3-position bring about unusual cyclodimerization under the influence of trifluoromethanesulfonic acid, to give a cis/trans-isomer mixture of substituted 1,3-dioxanes via neighboring carbonyl-group participation, cation transfer including phenonium rearrangement, and cyclodimerization. Oxiranes having a carbonyl functional group also undergo a similar cyclodimerization to form a 1,3-dioxolane ring. No phenyl substituent is required in the cases of the oxiranes, because the cation transfer process involves a 1,2-hydride shift alone. These five- and six-membered cyclic acetals are quite different from ring-expanded cyclic ether dimers expected simply from the back-biting reaction known in the cationic ring-opening polymerization of oxiranes and oxetanes.