Quantification of the sixth DNA base hydroxymethylcytosine in the brain
Mind over matter: LC-MS has allowed the amount of the post-replicatively formed DNA base 5hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy. (Figure Presented)
Muenzel, Martin,Globisch, Daniel,Brueckl, Tobias,Wagner, Mirko,Welzmiller, Veronika,Michalakis, Stylianos,Mueller, Markus,Biel, Martin,Carell, Thomas
Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups
The consecutive arrangement of 2′-deoxy-6-thioguanosines (s 6Gs) and 4-thiothymidines (s4Ts) in antiparallel triplex-forming oligonucleotides (TFOs) considerably stabilized the resulting antiparallel triplexes with high base recognit
4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNA
The formation of interstrand cross-links in nucleic acids can have a strong impact on biological function of nucleic acids; therefore, many cross-linking agents have been developed for biological applications. Despite numerous studies, there remains a nee
SYNTHESIS OF 4-C SUBSTITUTED PYRIMIDINE NUCLEOSIDES
t-Butyldimethylsilyl protected uridine and thyimidine were converted to the 4-O-triisopropylsulfonyl derivatives 3 and 4, respectively. 3 and 4 underwent clean displacements with mmalonate-type nucleophiles yielding the 4-C-substituted pyrimidine nucleosi
Bischofberger, Norbert
p. 2821 - 2824
(2007/10/02)
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