142409-74-3

Upstream product

• 1001-58-7 3-mercaptopropionitrile 
• 136743-13-0 5'-O-(4,4'-Dimethoxytrityl)-4-(S-p-nitrophenyl)-thiothymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 869355-26-0 C₁₃H₁₇N₃O₄S 
• 114021-22-6 3',5'-Bis-O-(tert-butyldimethylsilyl)-4-O-<(2,4,6-triisopropylphenyl)sulfonyl>thymidine 
• 1418736-29-4 C₂₅H₄₅N₃O₄SSi₂ 
• 142409-72-1 Phenoxy-acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 142409-76-5 Phenoxy-acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[5-methyl-4-(4-nitro-phenylsulfanyl)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 142409-73-2 Phenoxy-acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(2-cyano-ethylsulfanyl)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 

Downstream Products

• 1290537-73-3 C₄₃H₅₂N₅O₇PS 

Relevant academic research and scientific papers

Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups

The consecutive arrangement of 2′-deoxy-6-thioguanosines (s 6Gs) and 4-thiothymidines (s4Ts) in antiparallel triplex-forming oligonucleotides (TFOs) considerably stabilized the resulting antiparallel triplexes with high base recognit

Straightforward Preparation and Use in Oligodeoxynucleotide Synthesis of 5'-O-(4,4'-Dimethoxytrityl)-4-Thiothymidine

The title compound was prepared in four steps and 62percent yield from thymidine.After incorporation into synthetic oligodeoxynucleotides, the S-(2-cyanoethyl) group was removed by treatment with DBU in CH3CN to give products containing 4-thiothymidine residues.