- 99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma-2 Receptor Ligands for Tumor Imaging
-
We have designed and synthesized a series of cyclopentadienyl tricarbonyl rhenium complexes containing a 5,6-dimethoxyisoindoline or a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline pharmacophore as σ2 receptor ligands. Rhenium compound 20a posse
- Li, Dan,Chen, Yuanyuan,Wang, Xia,Deuther-Conrad, Winnie,Chen, Xin,Jia, Bing,Dong, Chengyan,Steinbach, J?rg,Brust, Peter,Liu, Boli,Jia, Hongmei
-
p. 934 - 946
(2016/02/23)
-
- COMPOSITIONS AND METHODS FOR TREATING CANCER
-
The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.
- -
-
Page/Page column 39
(2013/03/28)
-
- Isoindoline derivatives and processes for their preparation
-
A compound having the formula: STR1 wherein R is a hydrogen atom, a lower alkyl group, an alkanoyl group, an aralkyl group, an alkylsulfonyl group or an arylsulfonyl group, and R1 is a hydrogen atom or a protecting group for a hydroxyl group, o
- -
-
-
- Process for the production of isoindoline derivatives, novel intermediates and process for their production
-
A process for producing a compound of the formula: STR1 wherein R1 is a hydrogen atom, a lower alkyl group or an aralkyl group, and R2 is a hydrogen atom or a hydroxyl-protecting group, or a salt thereof, which comprises removing fro
- -
-
-