Novel pyrrolidine heterocycles as CCR1 antagonists
A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptab
Merritt, J. Robert,James, Ray,Paradkar, Vidyadhar M.,Zhang, Chongwu,Liu, Ruiyan,Liu, Jinqi,Jacob, Biji,Chiriac, Camelia,Ohlmeyer, Michael J.,Quadros, Elizabeth,Wines, Pamela,Postelnek, Jennifer,Hicks, Catherine M.,Chen, Weiqing,Kimble, Earl F.,O'Brien, Linda,White, Nicole,Desai, Hema,Appell, Kenneth C.,Webb, Maria L.
supporting information; experimental part
p. 5477 - 5479
(2010/12/24)
ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES and INFLAMMATION
Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.
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Page/Page column 10-11
(2009/04/24)
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