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(S)-7-(Trifluoromethyl)chroman-4-amine is a chiral chemical compound characterized by a molecular formula of C10H10F3NO. It features a chromane core structure with a trifluoromethyl group at the 7th position and an amine group at the 4th position. The presence of a stereocenter in (S)-7-(Trifluoromethyl)chroman-4-amine results in the existence of a pair of enantiomers. Its unique structure, particularly the trifluoromethyl group, can significantly influence the compound's chemical and biological properties, making it a promising candidate for pharmaceutical research and drug development.

1140496-05-4

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1140496-05-4 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(S)-7-(Trifluoromethyl)chroman-4-amine is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and the presence of a trifluoromethyl group contribute to its potential as a building block for other organic molecules, enhancing the development of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-7-(Trifluoromethyl)chroman-4-amine serves as a valuable compound for the design and optimization of new drugs. Its chiral nature and the trifluoromethyl group can be leveraged to modulate the compound's pharmacokinetic and pharmacodynamic properties, leading to improved drug efficacy and selectivity.
Used in Chemical Synthesis:
(S)-7-(Trifluoromethyl)chroman-4-amine is employed as a versatile building block in organic synthesis. Its unique structure allows for further functionalization and modification, enabling the creation of a wide range of chemical entities with diverse applications.
Further studies are required to fully explore the potential uses and properties of (S)-7-(Trifluoromethyl)chroman-4-amine, as its unique structure and the presence of a trifluoromethyl group offer promising avenues for pharmaceutical research, drug development, and chemical synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 1140496-05-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,0,4,9 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1140496-05:
(9*1)+(8*1)+(7*4)+(6*0)+(5*4)+(4*9)+(3*6)+(2*0)+(1*5)=124
124 % 10 = 4
So 1140496-05-4 is a valid CAS Registry Number.

1140496-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S)-7-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1140496-05-4 SDS

1140496-05-4Relevant articles and documents

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Schmidt, Robert G.,Bayburt, Erol K.,Latshaw, Steven P.,Koenig, John R.,Daanen, Jerome F.,McDonald, Heath A.,Bianchi, Bruce R.,Zhong, Chengmin,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Lee, Chih-Hung,Faltynek, Connie R.,Gomtsyan, Arthur

, p. 1338 - 1341 (2011/04/23)

Novel chroman and tetrahydroquinoline ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that aryl substituents on the 7- or 8-position of both bicyclic scaffolds imparted the best in vitro potency at TRPV1. The most potent chroman ureas were assessed in chronic and acute pain models, and compounds with the ability to cross the blood-brain barrier were shown to be highly efficacious. The tetrahydroquinoline ureas were found to be potent CYP3A4 inhibitors, but replacement of bulky substituents at the nitrogen atom of the tetrahydroisoquinoline moiety with small groups such as methyl can minimize the inhibition.

ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES and INFLAMMATION

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Page/Page column 14, (2009/04/24)

Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

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