114213-69-3

Basic information

• Product Name: N-Methyl Gatifloxacin
• Synonyms: 1-Cyclopropyl-7-(3,4-dimethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid;N-Methyl Gatifloxacin;3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(3,4-diMethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-8-Methoxy-4-oxo-;1-Cyclopropyl-7-(3,4-diMethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-8-Methoxy -4-oxo-
• CAS NO: 114213-69-3
• Molecular Formula: C20H24FN3O4
• Molecular Weight: 389.42
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles
• Mol File: 114213-69-3.mol

Chemical Properties

• Melting Point: 191-193°C
• Boiling Point: 583.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.362±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly, Heated)
• PKA: 6.43±0.50(Predicted)
• CAS DataBase Reference: N-Methyl Gatifloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl Gatifloxacin(114213-69-3)
• EPA Substance Registry System: N-Methyl Gatifloxacin(114213-69-3)

Safety Data

• Hazardous Substances Data: 114213-69-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl Gatifloxacin is used as an impurity in the production of Gatifloxacin for its role in the synthesis process of the antibiotic. The presence of N-Methyl Gatifloxacin can affect the quality and efficacy of the final product, making it an important consideration in the manufacturing process.
Used in Research and Development:
N-Methyl Gatifloxacin serves as a subject of study in research and development for its potential applications and effects on the properties of Gatifloxacin. Understanding the behavior and interactions of N-Methyl Gatifloxacin can lead to improvements in the synthesis and formulation of fluoroquinolone antibiotics.
Used in Quality Control and Analysis:
In the quality control and analysis of Gatifloxacin, N-Methyl Gatifloxacin is used as a reference compound to ensure the purity and potency of the antibiotic. By monitoring the levels of this impurity, manufacturers can maintain the desired standards for the drug's effectiveness and safety.
Used in Environmental and Industrial Applications:
Although not explicitly mentioned in the provided materials, N-Methyl Gatifloxacin may also have potential applications in environmental and industrial settings, such as in the treatment of water or waste containing traces of Gatifloxacin, due to its structural similarity and potential interactions with the antibiotic. Further research would be required to explore these possibilities.

Upstream product

• 50-00-0 formaldehyd 
• 160738-57-8 gatifloxacin 

Relevant articles and documents

N-methyl gatifloxacin acetal 4-aryl thiosemicarbazide derivative, and preparation method and application thereof

The invention discloses an N-methyl gatifloxacin acetal 4-aryl thiosemicarbazide derivative, and a preparation method and application thereof. The N-methyl gatifloxacin acetal 4-aryl thiosemicarbazide derivative adopts a chemical structural general formula as shown in formula I as follows: (shown in the description); in the formula I, a substituent group Ar is a benzene ring, a substitutive benzene ring, a pyridine ring, a furan ring or a thiophene ring. According to the N-methyl gatifloxacin acetal 4-aryl thiosemicarbazide derivative disclosed by the invention, the combination of three superior pharmacophores including a fluoroquinolone skeleton, Schiff base imide and thiourea is realized, so that the anti-tumor activity of a new compound is increased, toxic and side effects on normal cells are reduced, and the N-methyl gatifloxacin acetal 4-aryl thiosemicarbazide derivative can be used as an anti-tumor activity substance for developing an anti-tumor drug of a brand new structure.

N-methyl gatifloxacin (rhodanine unsaturated ketone) amide derivative, preparation method and applications thereof

The invention discloses a N-methyl gatifloxacin (rhodanine unsaturated ketone) amide derivative, a preparation method and applications thereof, wherein the chemical structure general formula represented by the following formula I is used, and in the formula I, Ar is a benzene ring or a substituted benzene ring or a furan ring or a pyridine ring. According to the present invention, the N-methyl gatifloxacin (rhodanine unsaturated ketone) amide derivative achieves the combination of the four pharmacophores such as the quinolone skeleton, the amide, the rhodanine and alpha,beta-unsaturated ketone so as to increase the anti-tumor activity of the new compound and reduce the toxic-side effects on normal cells, such that the N-methyl gatifloxacin (rhodanine unsaturated ketone) amide derivative can be adopted as the anti-tumor active substance so as to develop the anti-tumor drug having the completely-new structure.

N-methyl gatifloxacin aldehyde thiosemicarbazone derivative and preparation method and application thereof

The invention discloses N-methyl gatifloxacin aldehyde thiosemicarbazone derivative and a preparation method and application thereof. The N-methyl gatifloxacin aldehyde thiosemicarbazone derivative has a chemical structural formula as a following formula I. In the formula I, substituent R is an H atom or alkyl or cyclopropyl with 1 to 5 carbon atoms. According to the N-methyl gatifloxacin aldehyde thiosemicarbazone derivative disclosed by the invention, combination of three kinds of advantage pharmacophore of a fluoroquinolone framework, imine Schiff base, thiourea and the like is achieved; thus, antineoplastic activity of novel compound is improved, a toxic and side effect of normal cells is reduced, and the N-methyl gatifloxacin aldehyde thiosemicarbazone derivative can serve as antineoplastic activity substance to develop antineoplastic drug with a novel structure.

Quinoline-3-carboxylic acid derivatives

Compounds of formula (I): STR1 (in which R1 is alkoxy, R is alkyl, haloalkyl, alkylamino, cycloalkyl or optionally substituted phenyl, X is chlorine or fluorine and Y is selected from certain specific heterocycles) have excellent antibacterial activity. They may be prepared by introducing the group represented by Y into the corresponding compound in which Y is replaced by a halogen atom.