N-Methyl Gatifloxacin

Base Information

• Chemical Name: N-Methyl Gatifloxacin
• CAS No.: 114213-69-3
• Molecular Formula: C₂₀H₂₄FN₃O₄
• Molecular Weight: 389.427
• Mol file: 114213-69-3.mol

Synonyms:1-Cyclopropyl-7-(3,4-dimethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid;N-Methyl Gatifloxacin

Chemical Property of N-Methyl Gatifloxacin

Chemical Property:

• Melting Point: 191-193°C
• Boiling Point: 583.7±50.0 °C(Predicted)
• PKA: 6.43±0.50(Predicted)
• PSA: 75.01000
• Density: 1.362±0.06 g/cm3(Predicted)
• LogP: 2.32550
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl gatifloxacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Gatifloxacin. An impurity of Gatifloxacin

Technology Process of N-Methyl Gatifloxacin

There total 2 articles about N-Methyl Gatifloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + gatifloxacin (160738-57-8,112811-59-3) → N-methylgatifloxacin (114213-69-3)

Guidance literature:

With formic acid; for 12h; Reflux;

Reference yield:

→ N-methylgatifloxacin (114213-69-3)

Guidance literature:

Reference yield:

N-methylgatifloxacin (114213-69-3) → C30H30FN5O4S2

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 24 h / Reflux

2: water / Reflux

3: acetic acid; sodium acetate / 12 h / Reflux

With sodium acetate; hydrazine hydrate; acetic acid; In ethanol; water;

upstream raw materials:

formaldehyd

gatifloxacin

Refernces

• 1、 -. "N-methyl gatifloxacin (rhodanine unsaturated ketone) amide derivative, preparation method and applications thereof". Paragraph 0014. . Retrieved 2017/08/27.
• 2、 -. "Quinoline-3-carboxylic acid derivatives". . . Retrieved 2008/06/13.