1142227-35-7Relevant articles and documents
Seven-membered ring compound and application thereof in prevention and treatment of diabetes and metabolic syndrome
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, (2020/06/09)
The invention discloses a seven-membered ring compound and application thereof in prevention and treatment of diabetes and metabolic syndrome. The structure of the seven-membered ring compound is as shown in a general formula I, and definitions of substituent groups are as shown in the specification and claims. The seven-membered ring compound of the invention has an extremely excellent effect ofpreventing or treating diabetes and metabolic syndrome.
N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF
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Page/Page column 0153; 0154, (2019/01/04)
The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the formula.
BROMODOMAIN INHIBITOR
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Paragraph 0279, (2016/10/31)
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
BROMODOMAIN INHIBITORS
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Paragraph 0526; 0527, (2015/04/28)
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
SPIROCYCLIC GPR40 MODULATORS
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Page/Page column 141, (2010/04/30)
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also
CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS
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, (2009/10/22)
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.