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114460-08-1

1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE is a chemical compound belonging to the benzodiazepine class of drugs. It is a psychoactive substance known for its sedative, anxiolytic, and hypnotic properties. 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE is structurally related to benzodiazepines and has been investigated for its potential therapeutic use in treating anxiety, insomnia, and other central nervous system disorders. Its chemical structure, which includes an aminophenyl group, a methyl group, and a methylenedioxy group, plays a significant role in its pharmacological effects. While it may have potential medical applications, it also carries a risk of abuse and dependence, necessitating cautious use.

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  • 1-(4-aminoPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE

    Cas No: 114460-08-1

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  • Benzenamine,4-(8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-

    Cas No: 114460-08-1

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  • 114460-08-1 Structure

  • Basic information

    1. Product Name: 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE
    2. Synonyms: GYKI 52895;1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE;4-(8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline
    3. CAS NO:114460-08-1
    4. Molecular Formula: C17H17N3O2
    5. Molecular Weight: 295.34
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 114460-08-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 494.5°Cat760mmHg
    3. Flash Point: 252.8°C
    4. Appearance: white/solid
    5. Density: 1.4g/cm3
    6. Vapor Pressure: 6.43E-10mmHg at 25°C
    7. Refractive Index: 1.699
    8. Storage Temp.: N/A
    9. Solubility: ethanol: soluble
    10. CAS DataBase Reference: 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE(114460-08-1)
    12. EPA Substance Registry System: 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE(114460-08-1)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 22-26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114460-08-1(Hazardous Substances Data)

114460-08-1 Usage

Uses

Used in Pharmaceutical Industry:
1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE is used as a therapeutic agent for the treatment of anxiety and insomnia. Its anxiolytic and sedative properties make it a potential candidate for managing central nervous system disorders.
Used in Research and Development:
In the field of neuroscience and pharmacology, 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE is used as a research compound to study the effects of benzodiazepines on the central nervous system and to develop new medications with improved safety profiles and reduced potential for abuse.
Used in Drug Abuse Prevention and Treatment:
Due to its potential for abuse and dependence, 1-(4-AMINOPHENYL)-4-METHYL-7,8-METHYLENEDIOXY-3.4-DIHYDRO-5H-2,3-BENZODIAZEPINE may also be utilized in the development of strategies and treatments aimed at preventing and managing substance abuse, particularly related to benzodiazepines.

Check Digit Verification of cas no

The CAS Registry Mumber 114460-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,4,6 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 114460-08:
(8*1)+(7*1)+(6*4)+(5*4)+(4*6)+(3*0)+(2*0)+(1*8)=91
91 % 10 = 1
So 114460-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H17N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8,10,19H,6,9,18H2,1H3

114460-08-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114460-08-1 SDS

114460-08-1Relevant articles and documents

A simple and efficient synthesis of GYKI 52466 and GYKI 52895

Zappala, Maria,Grasso, Silvana,Micale, Nicola,Polimeni, Santina,De Micheli, Carlo

, p. 527 - 533 (2007/10/03)

The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine and acid addition salts thereof same

-

, (2008/06/13)

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ST

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