114564-74-8

Basic information

• Product Name: (4-Methyl-2-phenyloxazol-5-yl)-acetic acid ethyl ester
• Synonyms: (4-Methyl-2-phenyloxazol-5-yl)-acetic acid ethyl ester
• CAS NO: 114564-74-8
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245
• EINECS: -0
• Mol File: 114564-74-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Methyl-2-phenyloxazol-5-yl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methyl-2-phenyloxazol-5-yl)-acetic acid ethyl ester(114564-74-8)
• EPA Substance Registry System: (4-Methyl-2-phenyloxazol-5-yl)-acetic acid ethyl ester(114564-74-8)

Safety Data

• Hazardous Substances Data: 114564-74-8(Hazardous Substances Data)

Upstream product

• 2198-64-3 N-Benzoylalanine 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 17577-28-5 (ethoxycarbonylmethyl)triphenylphosphonium chloride 

Downstream Products

• 496063-05-9 methyl 2-{5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-6-phenyl-2,3-dihydro-1H-inden-1-yl}butanoate 
• 496060-84-5 2-{6-bromo-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid 
• 496063-04-8 C₂₆H₂₈BrNO₄ 
• 496063-01-5 2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester 
• 227029-27-8 2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate 
• 496060-86-7 methyl 2-{6-(4-chlorophenyl)-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoate 
• 17944-68-2 2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethanol 
• 496062-48-7 {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetic acid 
• 496062-47-6 ethyl {(1S)-5-[2-(4-methyl-2-phenyl-1,3-oxazol-5-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}acetate 

Relevant articles and documents

METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.

One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N′-diisopropylcarbodiimide and Wittig olefination

By a combination of cyclodehydration of N-acyl amino acids with N,N′-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3PCHCN and Ph 3PCHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, respectively.

5-Oxazolones, IV Reactions of 5(4H)-Oxazolones with Triphenylphosphonium Methylides

The Wittig reaction of ethyl (triphenylphosphoranylidene)acetate (2a) with the carbonyl group of trisubstituted 5(4H)-oxazolones 1a-c afforded ethyl 5(4H)-oxazolylideneacetates 3a-c and triphenylphosphane oxide.Starting from oxazolones 1d-i and ylide 2a, methyleneoxazoles 3d, e and ethyl 5-oxazoleacetates 4a-f were obtained besides ylides 5a-e deriving from the nucleophilic attack of the ylide at 1 and subsequent opening of the oxazole ring.Oxazolones 1a-c reacted also with triphenylphosphonium phenylmethylide (2b) to yield methyleneoxazoles 3f,g and ylides 5f-h.By treating triphenylphosphonium methylide (2c) and -methoxymethylide (2d) with 1a-c only open-chain compounds 5i-k and 5l-n, respectively, were obtained.