1145678-74-5

Basic information

• Product Name: (1-Tosyl-1H-indol-4-yl)methanamine
• Synonyms: (1-Tosyl-1H-indol-4-yl)methanamine
• CAS NO: 1145678-74-5
• Molecular Formula: C₁₆H₁₆N₂O₂S
• Molecular Weight: 300.37544
• Mol File: 1145678-74-5.mol

Chemical Properties

• Boiling Point: 516.6±52.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.82±0.40(Predicted)
• CAS DataBase Reference: (1-Tosyl-1H-indol-4-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Tosyl-1H-indol-4-yl)methanamine(1145678-74-5)
• EPA Substance Registry System: (1-Tosyl-1H-indol-4-yl)methanamine(1145678-74-5)

Safety Data

• Hazardous Substances Data: 1145678-74-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(1-Tosyl-1H-indol-4-yl)methanamine is used as a precursor in the synthesis of various biologically active molecules, particularly in the development of pharmaceuticals. Its unique structure allows for the creation of compounds with potential therapeutic applications.
Used in Agrochemical Development:
In addition to pharmaceuticals, (1-Tosyl-1H-indol-4-yl)methanamine is also utilized as a starting material in the synthesis of agrochemicals, contributing to the development of products for agricultural applications.
Used in Medicinal Chemistry Research:
(1-Tosyl-1H-indol-4-yl)methanamine is used as a subject of study in medicinal chemistry for its potential anti-inflammatory and antitumor properties. Researchers are interested in exploring its interactions with biological targets to develop new treatments for various conditions.
Used in Organic Synthesis:
As a compound with a tosyl group, (1-Tosyl-1H-indol-4-yl)methanamine is used in organic synthesis for the preparation of a range of organic compounds, taking advantage of the reactivity and functional group manipulations possible with tosyl chemistry.
Used in Central Nervous System Research:
(1-Tosyl-1H-indol-4-yl)methanamine is used as a potential ligand for receptors in the central nervous system, making it a candidate for research into neurological disorders and the development of related therapeutic agents.

Upstream product

• 16136-52-0 4-cyanoindole 
• 98-59-9 p-toluenesulfonyl chloride 
• 31271-86-0 1-[(4-methylphenyl)sulfonyl]-1H-indole-4-carbonitrile 
• 1074-86-8 4-formyl indole 
• 79681-04-2 1-[(4-methyl-phenyl)-sulfonyl]-1H-indol-4-carboxaldehyde 
• 1425932-86-0 1-tosyl-1H-indole-4-carbaldehyde oxime 

Downstream Products

• 1313236-71-3 tert-butyl 4-allyl-4-((1-tosyl-1H-indol-4-yl)methylamino)piperidine-1-carboxylate 
• 1313236-98-4 9-(benzo[d]oxazol-2-yl)-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one 
• 1313236-73-5 tert-butyl 4-allyl-4-(N-((1-tosyl-1H-indol-4-yl)methyl)acrylamido)piperidine-1-carboxylate 
• 1313236-75-7 tert-butyl 2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undec-3-ene-9-carboxylate 
• 1313236-77-9 tert-butyl 2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecane-9-carboxylate 
• 1313236-80-4 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate 
• 1313236-82-6 9-(quinoxalin-2-yl)-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one 
• 1373766-35-8 9-(4,6-dimethylpyrimidin-2-yl)-1-((1-tosyl-1Hindol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one 
• 1425932-87-1 N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-((1-tosyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine 

Relevant articles and documents

SERINE/THREONINE PAK1 INHIBITORS

Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.

DIAZA-SPIRO[5.5]UNDECANES AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to compound of the formula (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.