- Synthesis method of bilastine intermediate
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The invention relates to a synthesis method of a bilastine intermediate. The synthesis method comprises the following steps: S1, carrying out a Friedel-Crafts reaction on phenethyl acetate and isobutyryl halide under catalysis of Lewis acid to generate an intermediate compound B; S2, hydrolyzing the intermediate compound B to remove ester groups under an alkaline or acidic condition to obtain an intermediate compound C; S3, carrying out a hydroxyl protection reaction on the intermediate compound C to obtain an intermediate compound D by adding benzyl or p-methoxybenzyl protection groups to theintermediate compound C; S4, carrying out a bromination reaction on the intermediate compound D to generate an intermediate compound E; S5, carrying out a rearrangement reaction on the intermediate compound E under catalysis of a metal reagent to generate an intermediate compound F; and S6, carrying out hydrogenation or oxidative deprotection on the intermediate compound F to generate a target compound bilastine intermediate methyl alpha,alpha-dimethyl-4-(2-hydroxyethyl)phenylacetate. The method provided by the invention has low raw material cost and simple requirements on equipment and experimental conditions, can realize industrial production, and has a high application value.
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Paragraph 0007; 0018-0019
(2020/02/14)
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- 4-(2-halogenated isobutyryl) phenylethanol derivative and preparation method thereof
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The invention provides a 4-(2-halogenated isobutyryl) phenylethanol derivative. The derivative is characterized in that the structural general formula of the 4-(2-halogenated isobutyryl) phenylethanolderivative is shown in the description, wherein X refers to Cl or Br, and Pg refers to a hydrogen atom or a hydroxyl protective group. The invention also discloses a preparation method of the 4-(2-halogenated isobutyryl) phenylethanol derivative. The preparation method of the 4-(2-halogenated isobutyryl) phenylethanol derivative has the advantages that the cost of raw materials is low, the reaction conditions are mild, and a higher industrial production application value is achieved.
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Page/Page column 7
(2019/10/01)
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- Adhesion promoting photoinitiators for UV cured coatings over metal surfaces
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Compounds containing both photoinitiator moieties and adhesion promoting moieties and coating formulations containing them are disclosed, in particular, durable UV cured primer layers for coil coatings. One embodiment includes a coated metal surface which comprises a metal substrate with at least one surface immediately adjacent to a coating layer comprising a photoinitiator chemically bound to an adhesion promoter is disclosed.
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