1145780-83-1Relevant articles and documents
Synthesis method of bilastine intermediate
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Paragraph 0007; 0018-0019, (2020/02/14)
The invention relates to a synthesis method of a bilastine intermediate. The synthesis method comprises the following steps: S1, carrying out a Friedel-Crafts reaction on phenethyl acetate and isobutyryl halide under catalysis of Lewis acid to generate an intermediate compound B; S2, hydrolyzing the intermediate compound B to remove ester groups under an alkaline or acidic condition to obtain an intermediate compound C; S3, carrying out a hydroxyl protection reaction on the intermediate compound C to obtain an intermediate compound D by adding benzyl or p-methoxybenzyl protection groups to theintermediate compound C; S4, carrying out a bromination reaction on the intermediate compound D to generate an intermediate compound E; S5, carrying out a rearrangement reaction on the intermediate compound E under catalysis of a metal reagent to generate an intermediate compound F; and S6, carrying out hydrogenation or oxidative deprotection on the intermediate compound F to generate a target compound bilastine intermediate methyl alpha,alpha-dimethyl-4-(2-hydroxyethyl)phenylacetate. The method provided by the invention has low raw material cost and simple requirements on equipment and experimental conditions, can realize industrial production, and has a high application value.
Adhesion promoting photoinitiators for UV cured coatings over metal surfaces
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, (2009/05/29)
Compounds containing both photoinitiator moieties and adhesion promoting moieties and coating formulations containing them are disclosed, in particular, durable UV cured primer layers for coil coatings. One embodiment includes a coated metal surface which comprises a metal substrate with at least one surface immediately adjacent to a coating layer comprising a photoinitiator chemically bound to an adhesion promoter is disclosed.