- Synthesis and cytoprotective antiulcer activity of 2- or 4-(1H-pyrazol- 1-yl)pyrimidine derivatives related to mepirizole and dulcerozine
-
(1H-Pyrazol-1-yl)-, (1H-imidazol-1-yl)-, and (1H-1,2,4-triazol-1- yl)pyrimidines were prepared and evaluated for cytoprotective antiulcer activity. Among them, 4-methoxy-6-methyl-2-(1H-pyrazol-1-yl)pyrimidine (18) showed potent inhibition of the HCl-ethanol-induced and water-immersion stress-induced ulcers in rats, as well as low acute toxicity.
- Ikeda, Masazumi,Maruyama, Kazumi,Nobuhara, Youichi,Yamada, Toshihiro,Okabe, Susumu
-
-
Read Online
- SYNTHESES OF NEW PYRAZOLE-DERIVED CHELATING LIGANDS
-
The preparations and spectral data for nine new N,N'-chelating ligands (5)-(13), each consisting of a pyrazole group N-linked to an azine or azole, are described.
- Steel, Peter J.,Constable, Edwin C.
-
p. 1601 - 1611
(2007/10/02)
-